ArticleExperimental and therapeutic medicine2013
An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease.
Article in Experimental and therapeutic medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Investigation of associations between ten polymorphisms and the risk of coronary artery disease in Southern Han Chinese.Journal of human genetics · 2016Pooled it
- Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis.PloS one · 2015Pooled it
- Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.International journal of molecular sciences · 2014Pooled it
- Association of the variants in the BUD13-ZNF259 genes and the risk of hyperlipidaemia.Journal of cellular and molecular medicine · 2014Trial
- Association ofBiomedical reports · 2026Article
- Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Polymorphism of rs599839 in theJournal of cardiovascular and thoracic research · 2023Article
- A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.Nature genetics · 2021Article
- Lipoprotein-associated phospholipase A2: The story continues.Medicinal research reviews · 2020Review
- Human Secretary Phospholipase A2 Mutations and Their Clinical Implications.Journal of inflammation research · 2020Review
- Interaction between nonsynonymous polymorphisms in PLA2G7 gene and smoking on the risk of coronary heart disease in a Chinese population.Journal of thrombosis and thrombolysis · 2018Article
- Impact of gender and age on the association of the BUD13-ZNF259 rs964184 polymorphism with coronary heart disease.Anatolian journal of cardiology · 2018Article
- Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy.Acta pharmacologica Sinica · 2016Article
- Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease.Human genomics · 2016Article
- Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA.BMC genomics · 2016Article
- Nonsynonymous polymorphisms in PLA2G7 gene are associated with the risk of coronary heart disease in a southern Chinese population.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Genetic determinants of long-term changes in blood lipid concentrations: 10-year follow-up of the GLACIER study.PLoS genetics · 2014Article
- Sex-specific association of the zinc finger protein 259 rs2075290 polymorphism and serum lipid levels.International journal of medical sciences · 2014Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous genome-wide association studies (GWAS) have revealed seven single nucleotide polymorphisms (SNPs) that affect lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity or levels in American and European individuals. A total of 290 coronary heart disease (CHD) patients, 198 non-CHD patients and 331 unrelated healthy volunteers were recruited for the present case-control study of Han Chinese. Four SNPs (rs964184 of ZNF259, rs7528419 of CELSR2 and rs7756935 and rs1805017 of PLA2G7) were shown to be significantly associated with CHD. The rs964184-G allele of the ZNF259 gene was identified as a risk factor of CHD in females (odds ratio (OR) =1.49, 95% confidence interval (CI) =1.00-2.22, P=0.05). The rs7528419-G allele of the CELSR2 gene was protective against CHD in males (OR=0.48, 95% CI=0.25-0.93, P=0.04). The other two alleles (rs7756935-C and rs1805017-A) of the PLA2G7 gene acted as protective factors against CHD in females (rs7756935-C: OR=0.59, 95% CI=0.35-1.00, P=0.05; rs1805017-A: OR=0.51, 95% CI=0.28-0.93, P=0.03). Moreover, rs1805017 of the PLA2G7 gene was associated with the severity of CHD only in females (r(2)=0.02, P=0.04). We identified four Lp-PLA(2)-associated SNPs significantly associated with CHD in a Han Chinese population. Specifically, rs7528419 was protective factor against CHD in males, while the other two SNPs (rs7756935 and rs1805017 of the PLA2G7 gene) were protective factors against CHD in females and rs964184 of the ZNF259 gene was regarded as a risk factor for CHD in females.
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