ArticleDiabetes care2013
Fasting glucose level and the risk of incident atherosclerotic cardiovascular diseases.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 5 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Genetic Determinants of Coronary Artery Disease in Type 2 Diabetes Mellitus Among Asian Populations: A Meta-Analysis.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review.Oral diseases · 2025Pooled it
- Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism.Nature genetics · 2023Pooled it
- Serum/plasma biomarkers and the progression of cardiometabolic multimorbidity: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Pooled it
- Effects of antihypertensive drugs losartan and levamlodipine besylate on insulin resistance in patients with essential hypertension combined with isolated impaired fasting glucose.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Trial
- Associations Between Noise-Induced Hearing Loss and the Risk of High Fasting Blood Glucose Among the Air Force Population.Safety and health at work · 2026Article
- Bootstrap-Augmented Analysis of Non-Linear Associations Between Glucose, hsCRP, and First Myocardial Infarction in a Cardiovascular Population.International journal of molecular sciences · 2026Article
- Nonlinear association between glycemic markers and incident cardio‑renal‑metabolic multimorbidity: two decades of follow‑up in the Tehran Lipid and Glucose Study.American journal of preventive cardiology · 2025Article
- Comparing the "Life's Essential 8" Scores of Older Adults Living With Cardiovascular Diseases: NHANES, 2013 to 2018.Journal of the American Heart Association · 2025Article
- Preconception hypoglycemia and adverse pregnancy outcomes in Chinese women aged 20-49 years: A retrospective cohort study in China.PLoS medicine · 2025Article
- The 14-year cumulative genetic high blood pressure and risk of type 2 diabetes in Korean: observational and Mendelian randomization evidence.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Observational
- Article
- To study the role of triglyceride glucose index (TyG Index) as a novel biomarker in patients of type 2 diabetes mellitus (T2DM) developing acute coronary syndrome (ACS).Journal of family medicine and primary care · 2025Article
- Article
- Association between glucose levels and all-cause mortality in cancer survivors: findings from NHANES 1999-2018.BMC public health · 2024Article
- An Evaluation of DNA Methylation Levels and Sleep in Relation to Hot Flashes: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Association of longitudinal trajectories of fasting plasma glucose with all-cause and cardiovascular mortality among a Chinese older population: a retrospective cohort study.BMC public health · 2024Article
- Non-linear associations of HOMA2-IR with all-cause mortality in general populations: insights from NHANES 1999-2006.BMC public health · 2024Article
- Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI.Frontiers in cardiovascular medicine · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveAlthough diabetes increases the risk of cardiovascular disease (CVD) and mortality, the dose-response relationship between fasting glucose levels below those diagnostic of diabetes with cardiovascular events has not been well characterized. RESEARCH DESIGN AND
methodsA prospective cohort study of more than one million Koreans was conducted with a mean follow-up of 16 years. A total of 1,197,384 Korean adults with no specific medical conditions diagnosed were classified by baseline fasting serum glucose level. Associations of fasting glucose level with CVD incidence and mortality, stroke incidence and mortality, and all-cause mortality were analyzed using multivariate proportional hazards regression.
resultsThe relationships between fasting glucose levels and CVD risks generally followed J-shape curves, with lowest risk in the glucose range of 85-99 mg/dL. As fasting glucose levels increased to >100 mg/dL, risks for CVD, ischemic heart disease, myocardial infarction, and thrombotic stroke progressively increased, but risk for hemorrhagic stroke did not. Fasting glucose levels <70 mg/dL were associated with increased risk of all stroke (hazard ratio 1.06, 95% CI 1.01-1.11) in men and (hazard ratio 1.11, 1.05-1.17) in women.
conclusionsBoth low glucose level and impaired fasting glucose should be considered as predictors of risk for stroke and coronary heart disease. The fasting glucose level associated with the lowest cardiovascular risk may be in a narrow range.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.