Modeling in clinical nutrition: does it add to patient care?

BACKGROUND/

objectivesRemarkable improvements in mathematical methodology combined with knowledge and data on the response of the human body to changes in nutrition, activity and environment have led to a rapid expansion of mathematical models that predict, describe and aggregate conclusions in nutrition. Although mathematical models in nutrition have made significant advances in predictive accuracy and physiological descriptions, these advances have compromised model simplicity, introducing obstacles to their widespread application and contribution to clinical care. The challenge of model complexity is moderated by delivery through well-designed software. SUBJECTS/

methodsWe reviewed several recent and novel web-based mathematical models related to nutrition and describe the successful application of a dynamic mathematical model to patient care implemented through counseling software in a recent weight-loss intervention. To illustrate the power of model transfer through software, we designed a Visual Basic macro within Microsoft Excel to deliver predictions from six well-established and validated resting energy expenditure formulas in children and adults.

resultsThe six resting energy expenditure models that were deployed using the Visual Basic Application developer ranged in technical complexity requiring decision trees, calculation of nonlinear terms or inclusion of multiple covariates. The developed software allows users to select specific models and desired units. After input of individual height, weight, age and sex data through a user form, individuals can effortlessly view predictions.

conclusionsAdvances in web-based and widely accessible software provide the capacity to deliver more accurate and physiologically realistic nutrition-related models, and ultimately translating model results to patient care.