ArticleJAMA pediatrics2013
Cost-effectiveness of screening strategies for identifying pediatric diabetes mellitus and dysglycemia.
Article in JAMA pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- ISPAD Clinical Practice Consensus Guidelines 2024: Type 2 Diabetes in Children and Adolescents.Hormone research in paediatrics · 2024Guideline
- Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2017 · on this mapGuideline
- Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches.Diabetologia · 2013Pooled it
- Fasting Biomarkers and Glycated Haemoglobin Identify Children With Excess Weight at Risk of Dysglycaemia and Guide Oral Glucose Tolerance Testing.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- The case for broader use of HOMA-IR in pediatric metabolic assessment: a narrative review.Frontiers in pediatrics · 2026Review
- Type 1 diabetes prediction in autoantibody-positive individuals: performance, time and money matter.Diabetologia · 2025Article
- Heterogeneity of circulating CXCR5-PD-1Acta diabetologica · 2023Article
- Perception and Awareness of Diabetes Risk and Reported Risk-Reducing Behaviors in Adolescents.JAMA network open · 2023Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- Prospective Test Performance of Nonfasting Biomarkers to Identify Dysglycemia in Children and Adolescents.Hormone research in paediatrics · 2023Article
- 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023.Diabetes care · 2023 · on this mapReview
- Review
- Youth prediabetes and type 2 diabetes: Risk factors and prevalence of dysglycaemia.Pediatric obesity · 2022Article
- Association between prediabetes diagnosis and body mass index trajectory of overweight and obese adolescents.Pediatric diabetes · 2020Article
- Identifying Prediabetes and Type 2 Diabetes in Asymptomatic Youth: Should HbA1c Be Used as a Diagnostic Approach?Current diabetes reports · 2018Review
- Staying Young at Heart: Cardiovascular Disease Prevention in Adolescents and Young Adults.Current treatment options in cardiovascular medicine · 2015Article
- Screening practices for identifying type 2 diabetes in adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2014Article
- Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveTo conduct a cost-effectiveness analysis of screening strategies for identifying children with type 2 diabetes mellitus and dysglycemia (prediabetes/diabetes).
designCost simulation study.
settingA one-time US screening program. STUDY
participantsA total of 2.5 million children aged 10 to 17 years.
interventionScreening strategies for identifying diabetes and dysglycemia.
main outcome measuresEffectiveness (proportion of cases identified), total costs (direct and indirect), and efficiency (cost per case identified) of each screening strategy based on test performance data from a pediatric cohort and cost data from Medicare and the US Bureau of Labor Statistics.
resultsIn the base-case model, 500 and 400 000 US adolescents had diabetes and dysglycemia, respectively. For diabetes, the cost per case was extremely high ($312 000-$831 000 per case identified) because of the low prevalence of disease. For dysglycemia, the cost per case was in a more reasonable range. For dysglycemia, preferred strategies were the 2-hour oral glucose tolerance test (100% effectiveness; $390 per case), 1-hour glucose challenge test (63% effectiveness; $571), random glucose test (55% effectiveness; $498), or a hemoglobin A1c threshold of 5.5% (45% effectiveness; $763). Hemoglobin A1c thresholds of 5.7% and 6.5% were the least effective and least efficient (ranges, 7%-32% and $938-$3370) of all strategies evaluated. Sensitivity analyses for diabetes revealed that disease prevalence was a major driver of cost-effectiveness. Sensitivity analyses for dysglycemia did not lead to appreciable changes in overall rankings among tests.
conclusionsFor diabetes, the cost per case is extremely high because of the low prevalence of the disease in the pediatric population. Screening for diabetes could become more cost-effective if dysglycemia is explicitly considered as a screening outcome.
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Registered trials
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