ArticleExperimental and therapeutic medicine2013
Protective effect of endogenous hydrogen sulfide against oxidative stress in gastric ischemia-reperfusion injury.
Article in Experimental and therapeutic medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The cystathionine-γ-lyase inhibitor DL-propargylglycine augments the ability of L-cysteine ethyl ester to overcome the adverse effects of morphine on breathing.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Supplementation of sperm cryopreservation media with HScientific reports · 2024Article
- Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries.Antioxidants (Basel, Switzerland) · 2023Article
- Targeting Homocysteine and Hydrogen Sulfide Balance as Future Therapeutics in Cancer Treatment.Antioxidants (Basel, Switzerland) · 2023Review
- Protective Effects of HAntioxidants (Basel, Switzerland) · 2023Article
- Hydrogen sulfide-mediated resistance against water avoidance stress-induced gastritis by maintenance of gastric microbial homeostasis.MicrobiologyOpen · 2020Article
- Crocin enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress.American journal of translational research · 2020Article
- Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance.Antioxidants (Basel, Switzerland) · 2018Review
- Naringin improves random skin flap survival in rats.Oncotarget · 2017Article
- Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations.Molecules (Basel, Switzerland) · 2017Article
- Hydrogen sulfide attenuates gastric mucosal injury induced by restraint water-immersion stressWorld journal of gastroenterology · 2017Article
- Effects of Sanguis Draconis on Perforator Flap Survival in Rats.Molecules (Basel, Switzerland) · 2016Article
- Effects of diammonium glycyrrhizinate on random skin flap survival in rats: An experimental study.Biomedical reports · 2016Article
- Hydrogen Sulfide and Cellular Redox Homeostasis.Oxidative medicine and cellular longevity · 2016Review
- Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract.Microorganisms · 2015Review
- A cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway.International journal of cardiology. Heart & vasculature · 2015Article
- Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing.Molecules (Basel, Switzerland) · 2015Review
- Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury.Oxidative medicine and cellular longevity · 2015Review
- Organ-Protective Effects of Red Wine Extract, Resveratrol, in Oxidative Stress-Mediated Reperfusion Injury.Oxidative medicine and cellular longevity · 2015Review
- H2S during circulatory shock: some unresolved questions.Nitric oxide : biology and chemistry · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen sulfide (H(2)S) is a gaseous signaling molecule, which plays a critical role in a number of physiological and pathological progresses. In order to determine the effect of endogenous H(2)S on gastric ischemia-reperfusion (GI-R), we evaluated the gastric mucosal damage in rats intraperitoneally injected with DL-propargylglycine (PAG, 50 mg/kg/day) or L-cysteine (L-cys, 50 mg/kg/day) for 7 days before GI-R. GI-R injury was achieved by clamping the celiac artery for 30 min, followed by reperfusion for 60 min. Gastric mucosal damage was macroscopically assessed in the area of injury and deep damage was assessed by histopathological scoring. PAG increased the area of gastric mucosal injury and deep damage compared with that in untreated GI-R rats (P<0.05). While PAG decreased the H(2)S concentration and cystathionine γ-lyase (CSE) expression in the gastric mucosa, L-cys significantly attenuated the effects of GI-R. Western blot analysis revealed that the increases of malondialdehyde (MDA) and xanthine oxidase (XOD), and decreases of glutathione (GSH), superoxide dismutase (SOD) and the restriction of superoxide (O(2) (-)) production in the PAG group were inhibited by L-cys (P<0.05). Endogenous H(2)S has a protective effect against GI-R in rats by inhibiting oxygen free radical overproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.