ArticleNature communications2013
Allelic variation at a single gene increases food value in a drought-tolerant staple cereal.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Article
- Genome-Wide Identification, Characterization, and Expression Analysis of Four Subgroup Members of the GH13 Family in Wheat (International journal of molecular sciences · 2024Article
- Interplay of starch debranching enzyme and its inhibitor is mediated by Redox-Activated SPL transcription factor.Computational and structural biotechnology journal · 2022Article
- Hotter, drier, CRISPR: the latest edit on climate change.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Review
- Crop resistant starch and genetic improvement: a review of recent advances.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Review
- Functional Roles of Starch Binding Domains and Surface Binding Sites in Enzymes Involved in Starch Biosynthesis.Frontiers in plant science · 2018Review
- Domestication and the storage starch biosynthesis pathway: signatures of selection from a whole sorghum genome sequencing strategy.Plant biotechnology journal · 2016Article
- Structure and function of α-glucan debranching enzymes.Cellular and molecular life sciences : CMLS · 2016Review
- Molecular Approaches to Understand Nutritional Potential of Coarse Cereals.Current genomics · 2016Article
- Gene duplication confers enhanced expression of 27-kDa γ-zein for endosperm modification in quality protein maize.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Allelic variants in the PRR37 gene and the human-mediated dispersal and diversification of sorghum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Crystal structure of barley limit dextrinase-limit dextrinase inhibitor (LD-LDI) complex reveals insights into mechanism and diversity of cereal type inhibitors.The Journal of biological chemistry · 2015Article
- Exploiting Nutritional Value of Staple Foods in the World's Semi-Arid Areas: Risks, Benefits, Challenges and Opportunities of Sorghum.Healthcare (Basel, Switzerland) · 2015Review
- The future of starch bioengineering: GM microorganisms or GM plants?Frontiers in plant science · 2015Article
- Global integrated drought monitoring and prediction system.Scientific data · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The production of adequate agricultural outputs to support the growing human population places great demands on agriculture, especially in light of ever-greater restrictions on input resources. Sorghum is a drought-adapted cereal capable of reliable production where other cereals fail, and thus represents a good candidate to address food security as agricultural inputs of water and arable land grow scarce. A long-standing issue with sorghum grain is that it has an inherently lower digestibility. Here we show that a low-frequency allele type in the starch metabolic gene, pullulanase, is associated with increased digestibility, regardless of genotypic background. We also provide evidence that the beneficial allele type is not associated with deleterious pleiotropic effects in the modern field environment. We argue that increasing the digestibility of an adapted crop is a viable way forward towards addressing food security while maximizing water and land-use efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.