ArticleInfection and immunity2013
Phase variation of PorA, a major outer membrane protein, mediates escape of bactericidal antibodies by Neisseria meningitidis.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Rapid and recent evolution ofMicrobial genomics · 2026Article
- Genetic and Antigenic Diversity ofPathogens (Basel, Switzerland) · 2025Article
- Article
- Phase-variable expression of pdcB, a phosphodiesterase, influences sporulation in Clostridioides difficile.Molecular microbiology · 2021Article
- Article
- Meningococcal core and accessory phasomes vary by clonal complex.Microbial genomics · 2020Article
- Article
- Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence.PLoS biology · 2019Article
- Phase Variation ofMicrobiology spectrum · 2019Article
- Exploitation ofFrontiers in immunology · 2019Review
- Impact of meningococcal group B OMV vaccines, beyond their brief.Human vaccines & immunotherapeutics · 2018Article
- Genome-wide detection of conservative site-specific recombination in bacteria.PLoS genetics · 2018Article
- Issues in vaccinology: Present challenges and future directions.European journal of immunology · 2017Review
- Article
- In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes.BMC genomics · 2016Article
- The Clostridium difficile cell wall protein CwpV confers phase-variable phage resistance.Molecular microbiology · 2015Article
- Article
- Neisseria adhesin A variation and revised nomenclature scheme.Clinical and vaccine immunology : CVI · 2014Article
- Phase variation mediates reductions in expression of surface proteins during persistent meningococcal carriage.Infection and immunity · 2014Article
- Single cell stochastic regulation of pilus phase variation by an attenuation-like mechanism.PLoS pathogens · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several outer membrane proteins of Neisseria meningitidis are subject to phase variation due to alterations in simple sequence repeat tracts. The PorA protein is a major outer membrane protein and a target for protective host immune responses. Phase variation of PorA is mediated by a poly-G repeat tract present within the promoter, leading to alterations in protein expression levels. N. meningitidis strain 8047 was subjected to serial passage in the presence of P1.2, a PorA-specific bactericidal monoclonal antibody. Rapid development of resistance to bactericidal activity was associated with a switch in the PorA repeat tract from 11G to 10G. Phase variants with a 10G repeat tract exhibited a 2-fold reduction in surface expression of PorA protein. A mutS mutant of strain 8047, with an elevated phase variation rate, exhibited a higher rate of escape and an association of escape with 10G and 9G variants, the latter having a 13-fold reduction in surface expression of PorA. We conclude that graduated reductions in the surface expression of outer membrane proteins mediated by phase variation enable meningococci to escape killing in vitro by bactericidal antibodies. These findings indicate how phase variation could have a major impact on immune escape and host persistence of meningococci.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.