ArticleAntimicrobial agents and chemotherapy2013
Activities of systemically administered echinocandins against in vivo mature Candida albicans biofilms developed in a rat subcutaneous model.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients.Haematologica · 2017Guideline
- Combination of Systemic and Lock-Therapies with Micafungin Eradicate Catheter-Based Biofilms and Infections Caused byJournal of fungi (Basel, Switzerland) · 2024Article
- [Chinese expert consensus for invasive fungal disease in patients after hematopoietic stem cell transplantation(2023)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2023Article
- Bioactive Peptides Against Fungal Biofilms.Frontiers in microbiology · 2019Review
- Effect of Shikonin AgainstFrontiers in microbiology · 2019Article
- Review
- Pharmacodynamic and Immunomodulatory Effects of Micafungin on Host Responses against Biofilms of Candida parapsilosis in Comparison to Those of Candida albicans.Antimicrobial agents and chemotherapy · 2018Article
- Methodologies forMicrobial cell (Graz, Austria) · 2018Review
- Antifungal Activity of Oleylphosphocholine onAntimicrobial agents and chemotherapy · 2018Article
- Inhibitory activity of hinokitiol against biofilm formation in fluconazole-resistant Candida species.PloS one · 2017Article
- Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis.Frontiers in microbiology · 2017Review
- Inhibitory Effect of Sophorolipid on Candida albicans Biofilm Formation and Hyphal Growth.Scientific reports · 2016Article
- Candida albicans biofilm development on medically-relevant foreign bodies in a mouse subcutaneous model followed by bioluminescence imaging.Journal of visualized experiments : JoVE · 2015Article
- The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia.Antibiotics (Basel, Switzerland) · 2014Review
- High-content phenotypic screenings to identify inhibitors of Candida albicans biofilm formation and filamentation.Pathogens and disease · 2014Article
- Towards non-invasive monitoring of pathogen-host interactions during Candida albicans biofilm formation using in vivo bioluminescence.Cellular microbiology · 2014Article
- In vitro study of sequential fluconazole and caspofungin treatment against Candida albicans biofilms.Antimicrobial agents and chemotherapy · 2014Article
- Recent insights into Candida albicans biofilm resistance mechanisms.Current genetics · 2013Review
- Mechanisms of Candida biofilm drug resistance.Future microbiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study addresses the effects of micafungin, caspofungin, and anidulafungin against Candida albicans biofilms developed in a subcutaneous catheter rat model system. Doses of 5, 10, and 30 mg/kg (of body weight)/day (the last only for micafungin) were given intravenously for 5, 7, and 10 days. All three echinocandins caused a significant reduction of the Candida cell numbers on the implanted catheters and are thus promising for the treatment of biofilm-related infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.