ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2013
Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 61 citations in OpenAlex.
- Monte Carlo simulations of time-resolved blood flow index: times-of-flight beyond ∼1 ns are necessary for brain-dominated measurements.Neurophotonics · 2026Article
- Large Hypertransmission Defects Exhibit Choriocapillaris Flow Speed Impairment in Nonexudative Age-Related Macular Degeneration.Ophthalmology science · 2026Article
- Review of dynamic optical coherence tomography for intracellular motility: signals, metrics, and their applications [Invited].Biomedical optics express · 2025Review
- Mapping of blood flow and slow speckle tissue dynamics using laser speckle contrast imaging.Biomedical optics express · 2025Article
- Bessel beam optical coherence microscopy enables multiscale assessment of cerebrovascular network morphology and function.Light, science & applications · 2024Article
- Dynamic light scattering and laser speckle contrast imaging of the brain: theory of the spatial and temporal statistics of speckle pattern evolution.Biomedical optics express · 2024Article
- Measurements of slow tissue dynamics with short-separation speckle contrast optical spectroscopy.Biomedical optics express · 2023Article
- Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy.Journal of biomedical optics · 2023Article
- Imaging and characterization of transitions in biofilm morphology via anomalous diffusion following environmental perturbation.Biomedical optics express · 2022Article
- Validation of red blood cell flux and velocity estimations based on optical coherence tomography intensity fluctuations.Scientific reports · 2020Article
- Noise and bias in optical coherence tomography intensity signal decorrelation.OSA continuum · 2020Article
- Measuring cell displacements in opaque tissues: dynamic light scattering in the multiple scattering regime.Biomedical optics express · 2020Article
- Forward multiple scattering dominates speckle decorrelation in whole-blood flowmetry using optical coherence tomography.Biomedical optics express · 2020Article
- Dynamic light scattering optical coherence tomography to probe motion of subcellular scatterers.Journal of biomedical optics · 2019Article
- Doppler OCT clutter rejection using variance minimization and offset extrapolation.Biomedical optics express · 2018Article
- Standard-unit measurement of cellular viability using dynamic light scattering optical coherence microscopy.Biomedical optics express · 2018Article
- Biodynamic digital holography of chemoresistance in a pre-clinical trial of canine B-cell lymphoma.Biomedical optics express · 2018Article
- Shear-induced diffusion of red blood cells measured with dynamic light scattering-optical coherence tomography.Journal of biophotonics · 2018Article
- Visible spectrum extended-focus optical coherence microscopy for label-free sub-cellular tomography.Biomedical optics express · 2017Article
- Optical coherence tomography imaging of capillary reperfusion after ischemic stroke.Applied optics · 2016Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
This paper describes a novel optical method for label-free quantitative imaging of cerebral blood flow (CBF) and intracellular motility (IM) in the rodent cerebral cortex. This method is based on a technique that integrates dynamic light scattering (DLS) and optical coherence tomography (OCT), named DLS-OCT. The technique measures both the axial and transverse velocities of CBF, whereas conventional Doppler OCT measures only the axial one. In addition, the technique produces a three-dimensional map of the diffusion coefficient quantifying nontranslational motions. In the DLS-OCT diffusion map, we observed high-diffusion spots, whose locations highly correspond to neuronal cell bodies and whose diffusion coefficient agreed with that of the motion of intracellular organelles reported in vitro in the literature. Therefore, the present method has enabled, for the first time to our knowledge, label-free imaging of the diffusion-like motion of intracellular organelles in vivo. As an example application, we used the method to monitor CBF and IM during a brief ischemic stroke, where we observed an induced persistent reduction in IM despite the recovery of CBF after stroke. This result supports that the IM measured in this study represent the cellular energy metabolism-related active motion of intracellular organelles rather than free diffusion of intracellular macromolecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.