Evidence map›Paper›PMID 23403052›Full record

ArticleThe Journal of allergy and clinical immunology2013

Being overweight increases susceptibility to indoor pollutants among urban children with asthma.

Kim D Lu, Patrick N Breysse, Gregory B Diette, Jean Curtin-Brosnan, Charles Aloe, D'Ann L Williams, Roger D Peng, Meredith C McCormack, Elizabeth C Matsui

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 94 citations in OpenAlex.

  1. Trial
  2. Review
  3. Obesity: Next game changer of allergic airway diseases?Clinical and translational medicine · 2025
    Review
  4. Review
  5. Indoor air pollution and airway health.The Journal of allergy and clinical immunology · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022
    Review
  10. The influence of urban exposures and residence on childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Melatonin Alleviates PMOxidative medicine and cellular longevity · 2022
    Article
  15. Review
  16. Article
  17. Indoor Air Pollution and Respiratory Health.Clinics in chest medicine · 2020
    Review
  18. Obesity may enhance the adverse effects of NOThe Journal of allergy and clinical immunology · 2020
    Article
  19. Childhood Origins of Adult Lung Disease as Opportunities for Prevention.The journal of allergy and clinical immunology. In practice · 2020
    Article
  20. Aligning Community-Engaged Research to Context.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kim D LuDivision of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Patrick N Breysse
Gregory B Diette
Jean Curtin-Brosnan
Charles Aloe
D'Ann L Williams
Roger D Peng
Meredith C McCormack
Elizabeth C Matsui
Johns Hopkins University · US

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3M
Oxidative Stress & Inflammation in a Human PM Nasal ChallengeP50ES015903 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2007 to 2011
$12.1M
Multidisciplinary Training Program in Pediatric PulmonaryT32HL072748 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Joseph Michael Collaco · 2003 to 2026
$6.1M
Project 3: Dissecting the Diet Asthma Relationship in Mice Models of AsthmaP01ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI DIETTE, GREGORY B · 2009 to 2013
$4.2M
Mouse Allergen and Inner-City AsthmaR01AI070630 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2006 to 2010
$1.9M
Statistical Methods for Complex Enivronmental Health DataR01ES019560 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI PENG, ROGER · 2011 to 2015
$1.8M
Mentoring and Patient Oriented Research in AsthmaK24ES021098 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI DIETTE, GREGORY B · 2012 to 2016
$927k
NCRR NIH HHS M01 RR000052NCRR NIH HHS M01-RR00052NHLBI NIH HHS T32 HL072748NIAID NIH HHS R01 AI070630NIAID NIH HHS R01AI070630NIEHS NIH HHS K24 ES021098NIEHS NIH HHS P01 ES018176NIEHS NIH HHS P01ES018176NIEHS NIH HHS P50 ES015903NIEHS NIH HHS P50ES015903NIEHS NIH HHS R01 ES019560
6 · The paper itself

Abstract

backgroundBoth being overweight and exposure to indoor pollutants, which have been associated with worse health of asthmatic patients, are common in urban minority populations. Whether being overweight is a risk factor for the effects of indoor pollutant exposure on asthma health is unknown.

objectivesWe sought to examine the effect of weight on the relationship between indoor pollutant exposure and asthma health in urban minority children.

methodsOne hundred forty-eight children (age, 5-17 years) with persistent asthma were followed for 1 year. Asthma symptoms, health care use, lung function, pulmonary inflammation, and indoor pollutants were assessed every 3 months. Weight category was based on body mass index percentile.

resultsParticipants were predominantly African American (91%) and had public health insurance (85%). Four percent were underweight, 52% were normal weight, 16% were overweight, and 28% were obese. Overweight or obese participants had more symptoms associated with exposure to fine particulate matter measuring less than 2.5 μm in diameter (PM2.5) than normal-weight participants across a range of asthma symptoms. Overweight or obese participants also had more asthma symptoms associated with nitrogen dioxide (NO2) exposure than normal-weight participants, although this was not observed across all types of asthma symptoms. Weight did not affect the relationship between exposure to coarse particulate matter measuring between 2.5 and 10 μm in diameter and asthma symptoms. Relationships between indoor pollutant exposure and health care use, lung function, or pulmonary inflammation did not differ by weight.

conclusionBeing overweight or obese can increase susceptibility to indoor PM2.5 and NO2 in urban children with asthma. Interventions aimed at weight loss might reduce asthma symptom responses to PM2.5 and NO2, and interventions aimed at reducing indoor pollutant levels might be particularly beneficial in overweight children.

Indexed as

Black or African AmericanAdolescentAir PollutantsAir Pollution, IndoorAsthmaBaltimoreBody Mass IndexChildChild, PreschoolEnvironmental ExposureFemaleFollow-Up StudiesHumansInflammationLungMaleAir PollutantsNitrogen DioxideParticulate Matter

Identifiers

PMID23403052
PMCPMC3889705
OpenAlexW2115932417

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.