ArticleExperimental gerontology2013
High carbohydrate-low protein consumption maximizes Drosophila lifespan.
Article in Experimental gerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed.
- Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification.Aging cell · 2023Trial
- High-protein diet promotes aging by activating the CG6415/AMT gene and disrupting mitochondrial homeostasis.Journal of advanced research · 2026Article
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- No single host is optimal: effects of fruit species on development and adult performance inFrontiers in insect science · 2026Article
- Structure, function, and quantitative biology of the Drosophila gut microbiome.Current opinion in microbiology · 2025Review
- Aging-Related Obesity: Unveiling Mitochondrial and Metabolic Dysfunction.Current nutrition reports · 2025Review
- Reproduction and preference to macronutrients have different relations to biological or chronological age in Drosophila.Biogerontology · 2025Article
- Taste sensitivity and consumption responses to sucrose and artificial sweeteners inJournal of undergraduate research (Gainesville, Fla.) · 2025Article
- Sex, not yeast or atrazine concentration, affects virgin adultmicroPublication biology · 2025Article
- High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice.npj metabolic health and disease · 2025Article
- Dietary Variation Effect on Life History Traits and Energy Storage in Neotropical Species of Drosophila (Diptera; Drosophilidae).Neotropical entomology · 2024Article
- Diet-induced plasticity of life-history traits and gene expression in outbredEcology and evolution · 2024Article
- Misalignment of plastic and evolutionary responses of lifespan to novel carbohydrate diets.Royal Society open science · 2024Article
- Article
- When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging.Cell metabolism · 2023Review
- Sex-biased gene expression in nutrient-sensing pathways.Proceedings. Biological sciences · 2023Article
- Protein- and Carbohydrate-Rich Supplements in Feeding Adult Black Soldier Flies (Life (Basel, Switzerland) · 2023Article
- Article
- Amino Acid Availability Is Not Essential for Life-Span Extension by Dietary Restriction in the Fly.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Adherence to Mediterranean Diet and Soluble Klotho Level: The Value of Food Synergy in Aging.Nutrients · 2022Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohydrates also play a central role. To clarify how nutritional factors influence longevity, nutrient consumption and lifespan were measured on a series of diets with varying yeast and sugar content. We show that optimal lifespan requires both high carbohydrate and low protein consumption, but neither nutrient by itself entirely predicts lifespan. Increased dietary carbohydrate or protein concentration does not always result in reduced feeding-the regulation of food consumption is best described by a constant daily caloric intake target. Moreover, due to differences in food intake, increased concentration of a nutrient within the diet does not necessarily result in increased consumption of that particular nutrient. Our results shed light on the issue of dietary effects on lifespan and highlight the need for accurate measures of nutrient intake in dietary manipulation studies.
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Registered trials
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