ArticleClinical endocrinology2013
Parathyroid hormone and arterial dysfunction in the multi-ethnic study of atherosclerosis.
Article in Clinical endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Changes in vascular structure and function in primary hyperparathyroidism: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Pooled it
- Parathyroid hormone and risk of heart failure in the general population: A meta-analysis of prospective studies.Medicine · 2016Pooled it
- The Multi-Ethnic Study of Atherosclerosis individual response to vitamin D trial: Building a randomized clinical trial into an observational cohort study.Contemporary clinical trials · 2021Trial
- Research on vitamin D metabolic regulation in the pathogenesis of related diseases.Frontiers in endocrinology · 2026Review
- Increased arterial stiffness in normotensive individuals with hypoparathyroidism.Scientific reports · 2025Article
- Vitamin - D deficiency as a risk factor in primary hypertension - A cross sectional study.Bioinformation · 2025Article
- Revealing the mechanisms of warfarin-induced vascular calcification through metabolomics and network toxicology.Frontiers in pharmacology · 2025Article
- Associations of Vitamin D-Related Biomarkers With Hypertension and the Renin-Angiotensin System in Men and Women.American journal of hypertension · 2024Article
- Ethnic and seasonal variations in FGF-23 and markers of chronic kidney disease-mineral and bone disorder.Clinical kidney journal · 2024Article
- A Delicate Balance: Challenges in the Management of Primary Hyperparathyroidism and Congestive Heart Failure.Cureus · 2023Article
- Biomarkers of Vitamin D Metabolism and Hip and Vertebral Fracture Risk: The Multi-Ethnic Study of Atherosclerosis.JBMR plus · 2022Article
- Plasma Levels of Intact Parathyroid Hormone and Congestion Burden in Heart Failure: Clinical Correlations and Prognostic Role.Journal of cardiovascular development and disease · 2022Article
- Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension.Medicina (Kaunas, Lithuania) · 2021Article
- The association between Hba1c and arterial stiffness among non-diabetic patients with chronic kidney disease.Jornal vascular brasileiro · 2021Article
- Parathyroid hormone may play a role in the pathophysiology of primary hypertension.Endocrine connections · 2021Article
- Race, Ancestry, and Vitamin D Metabolism: The Multi-Ethnic Study of Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2020Article
- Impact of Race on the Association of Mineral Metabolism With Heart Failure: the Multi-Ethnic Study of Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2020Article
- Serum parathyroid hormone levels in patients with chronic right heart failure.Biomedical reports · 2020Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveHigh circulating concentrations of parathyroid hormone (PTH) have been associated with increased risks of hypertension, left ventricular hypertrophy, congestive heart failure and cardiovascular mortality. Impaired arterial function is a potential mechanism for these associations. We tested whether serum PTH concentration is associated with measures of arterial function.
designCross-sectional study.
participantsA total of 6545 persons without clinical cardiovascular disease participating in the community-based Multi-Ethnic Study of Atherosclerosis. MEASUREMENTS: Brachial artery flow-mediated dilation (FMD) as well as aortic pulse pressure and arterial pulse parameters derived from Windkessel modelling of the radial pressure waveform.
resultsHigher serum PTH concentration was associated with lower brachial artery FMD (mean difference -0·09% per 10 pg/ml PTH), higher aortic pulse pressure (0·53 mmHg per 10 pg/ml) and reduced Windkessel capacitive index C1 (large artery elasticity, -0·12 ml/mmHg × 10 per 10 pg/ml), adjusting for potential confounding variables (all P-values ≤ 0·001). These relationships were independent of serum calcium concentration, serum 25-hydroxyvitamin D concentration and estimated glomerular filtration rate and were consistent across relevant participant subgroups. Associations of PTH with aortic pulse pressure and capacitive index C1 were attenuated after adjustment for blood pressure. Serum PTH concentration was not associated with the oscillatory index C2 (small artery elasticity).
conclusionsHigher serum PTH concentration was associated with impaired endothelial function, increased aortic pulse pressure and decreased capacitive index C1 in a large, diverse, community-based population. These relationships may help explain previously observed associations of elevated PTH with cardiovascular disease.
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