ArticleJournal of the American Chemical Society2013
Controlled integration of gold nanoparticles and organic fluorophores using synthetically modified MS2 viral capsids.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Measuring the selective packaging of RNA molecules by viral coat proteins in cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Systematic engineering of virus-like particles to identify self-assembly rules for shifting particle size.Virology · 2023Article
- Article
- Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine-Cysteine Bond Formation.ACS central science · 2020Article
- Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics.Pharmaceutics · 2019Review
- Review
- Making Conjugation-induced Fluorescent PEGylated Virus-like Particles by Dibromomaleimide-disulfide Chemistry.Journal of visualized experiments : JoVE · 2018Article
- Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle.Nature communications · 2018Article
- Mechanistic insights into plasmonic photocatalysts in utilizing visible light.Beilstein journal of nanotechnology · 2018Review
- Display of single-chain variable fragments on bacteriophage MS2 virus-like particles.Journal of nanobiotechnology · 2017Article
- Phage-Enabled Nanomedicine: From Probes to Therapeutics in Precision Medicine.Angewandte Chemie (International ed. in English) · 2017Review
- Encapsulation of Inorganic Nanomaterials inside Virus-Based Nanoparticles for Bioimaging.Nanotheranostics · 2017Review
- Protein Nanoparticles as Multifunctional Biocatalysts and Health Assessment Sensors.Current opinion in chemical engineering · 2016Article
- Design of virus-based nanomaterials for medicine, biotechnology, and energy.Chemical Society reviews · 2016Review
- Article
- A novel method to produce armored double-stranded DNA by encapsulation of MS2 viral capsids.Applied microbiology and biotechnology · 2015Article
- Synthetically Modified Viral Capsids as Versatile Carriers for Use in Antibody-Based Cell Targeting.Bioconjugate chemistry · 2015Article
- Photonics and plasmonics go viral: self-assembly of hierarchical metamaterials.Rendiconti Lincei. Scienze fisiche e naturali · 2015Article
- N-terminal modification of proteins with o-aminophenols.Journal of the American Chemical Society · 2014Article
- Formation mechanism of chalcogenide nanocrystals confined inside genetically engineered virus-like particles.Scientific reports · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
The placement of fluorophores in close proximity to metal nanoparticle surfaces is proposed to enhance several photophysical properties of the dyes, potentially leading to improved quantum yields and decreased photobleaching. It is difficult in practice, however, to establish and maintain the nanoscale distances that are required to maximize these effects. The type of metal, size, and shape of the nanoparticle, the physical distance separating the metal nanoparticle from the organic dye, and the spectral properties of the fluorophore itself are all proposed to influence the quantum yield and lifetime. This results in a complex behavior that can lead to either enhanced or quenched fluorescence in different contexts. In this report, we describe a well-defined system that can be used to explore these effects, while physically preventing the fluorophores from contacting the nanoparticle surfaces. The basis of this system is the spherical protein capsid of bacteriophage MS2, which was used to house gold particles within its interior volume. The exterior surface of each capsid was then modified with Alexa Fluor 488 (AF 488) labeled DNA strands. By placing AF 488 dyes at distances of 3, 12, and 24 bp from the surface of capsids containing 10 nm gold nanoparticles, fluorescence intensity enhancements of 2.2, 1.2, and 1.0 were observed, respectively. A corresponding decrease in fluorescence lifetime was observed for each distance. Because of its well-defined and modular nature, this architecture allows the rapid exploration of the many variables involved in metal-controlled fluorescence, leading to a better understanding of this phenomenon.
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