ReviewJournal of obesity2013
The role of adipose tissue in insulin resistance in women of African ancestry.
Review in Journal of obesity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Prevalence of Type 2 Diabetes in South Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- How do social determinants and legal status affect the health of undocumented migrants in France?BMC public health · 2026Article
- Obesity Pillars Roundtable: Body mass index and body composition in Black and Female individuals. Race-relevant or racist? Sex-relevant or sexist?Obesity pillars · 2022Article
- Relationships between adiposity distribution and metabolic health in preconception women in South Africa.Obesity science & practice · 2022Article
- A Matter of Fat: Body Fat Distribution and Cardiometabolic Disease in Africa.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry.Antioxidants (Basel, Switzerland) · 2021Review
- Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study.Nutrients · 2020Article
- The discriminatory power of visceral adipose tissue area vs anthropometric measures as a diagnostic marker for metabolic syndrome in South African women.Diabetology & metabolic syndrome · 2019Article
- Different adiposity indices and their association with blood pressure and hypertension in middle-aged urban black South African men and women: findings from the AWI-GEN South African Soweto Site.BMC public health · 2018Article
- Obesity and Triple-Negative Breast Cancer: Disparities, Controversies, and Biology.The American journal of pathology · 2018Review
- The association between high-sensitivity C-reactive protein and metabolic risk factors in black and white South African women: a cross-sectional study.BMC obesity · 2018Article
- Obesity, weight gain, and ovarian cancer risk in African American women.International journal of cancer · 2016Article
- The Role of Body Fat and Fat Distribution in Hypertension Risk in Urban Black South African Women.PloS one · 2016Article
- Racial and ethnic disparities in the impact of obesity on breast cancer risk and survival: a global perspective.Advances in nutrition (Bethesda, Md.) · 2015Review
- Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium.Breast cancer research and treatment · 2015Article
- The relationship between dietary fatty acids and inflammatory genes on the obese phenotype and serum lipids.Nutrients · 2013Review
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Women of African ancestry, particularly those living in industrialized countries, experience a disproportionately higher prevalence of type 2 diabetes (T2D) compared to their white counterparts. Similarly, obesity and insulin resistance, which are major risk factors for T2D, are greater in black compared to white women. The exact mechanisms underlying these phenomena are not known. This paper will focus on the role of adipose tissue biology. Firstly, the characteristic body fat distribution of women of African ancestry will be discussed, followed by the depot-specific associations with insulin resistance. Factors involved in adipose tissue biology and their relation to insulin sensitivity will then be explored, including the role of sex hormones, glucocorticoid metabolism, lipolysis and adipogenesis, and their consequent effects on adipose tissue hypoxia, oxidative stress, and inflammation. Finally the role of ectopic fat deposition will be discussed. The paper proposes directions for future research, in particular highlighting the need for longitudinal and/or intervention studies to better understand the mechanisms underlying the high prevalence of insulin resistance and T2D in women of African ancestry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.