ArticleRadiology2013
US elastography-derived shear wave velocity helps distinguish acutely inflamed from fibrotic bowel in a Crohn disease animal model.
Article in Radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 103 citations in OpenAlex.
- Integrating Intestinal Ultrasound in the Personalized Management of IBD.Journal of personalized medicine · 2026Review
- Assessing intestinal fibrosis using an endoscopic photoacoustic-ultrasound balloon catheter in rabbits and a human subject.Journal of Crohn's & colitis · 2025Article
- Shear wave elastography primer for the abdominal radiologist.Abdominal radiology (New York) · 2025Review
- Fibrosis: cross-organ biology and pathways to development of innovative drugs.Nature reviews. Drug discovery · 2025Review
- Elastographic Histogram Analysis as a Non-Invasive Tool for Detecting Early Intestinal Remodeling in Experimental IBD.Journal of clinical medicine · 2025Article
- Real-time shear wave elastography in measuring normal ileocolon intestinal wall stiffness using colonoscopy as reference: A single-center research.European journal of radiology open · 2025Article
- Ultrasound elastography in dogs: Physical principles and application in intestinal evaluation.Veterinary world · 2024Review
- Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease.EMBO molecular medicine · 2024Article
- Multimodal dynamic ultrasound approach as predictor of response in patients with Crohn's disease treated with ustekinumab.Therapeutic advances in gastroenterology · 2024Article
- How to Evaluate Fibrosis in IBD?Diagnostics (Basel, Switzerland) · 2023Review
- Retrospective Cohort Study of Shear-Wave Elastography and Computed Tomography Enterography in Crohn's Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Ultrasound shear wave elastography in pediatric stricturing small bowel Crohn disease: correlation with histology and second harmonic imaging microscopy.Pediatric radiology · 2023Article
- Pancreatic shear wave elastography in children with type 1 diabetes: relation to diabetes duration, glycemic indices, fasting C-peptide and diabetic complications.Pediatric radiology · 2022Article
- Role of Multiparametric Intestinal Ultrasound in the Evaluation of Response to Biologic Therapy in Adults with Crohn's Disease.Diagnostics (Basel, Switzerland) · 2022Review
- Prototype endoscopic photoacoustic-ultrasound balloon catheter for characterizing intestinal obstruction.Biomedical optics express · 2022Article
- Tuberculous Granuloma: Emerging Insights From Proteomics and Metabolomics.Frontiers in neurology · 2022Review
- Ultrasound Elastography in the Assessment of the Intestinal Changes in Inflammatory Bowel Disease-Systematic Review.Journal of clinical medicine · 2021Review
- Shear Wave and Strain Elastography in Crohn's Disease-A Systematic Review.Diagnostics (Basel, Switzerland) · 2021Review
- Using shear wave elasticity in normal terminal ileum of a healthy southwest Chinese population: a pilot study of reference elasticity ranges.Quantitative imaging in medicine and surgery · 2021Article
- Paediatric gastrointestinal and hepatobiliary radiology: why do we need subspecialists, and what is new?Pediatric radiology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine if acoustic radiation force impulse elastography-derived bowel wall shear wave velocity (SWV) allows distinction of acutely inflamed from fibrotic intestine in a Crohn disease animal model. MATERIALS AND
methodsUniversity Committee on the Use and Care of Animals approval was obtained. An acute inflammation Crohn disease model was produced by treating eight Lewis rats with a single administration of trinitrobenzenesulfonic acid (TNBS) enema, with imaging performed 2 days later in the surviving six rats. Colonic fibrosis in an additional eight Lewis rats was achieved by administering repeated TNBS enemas during 4 weeks, with imaging performed in the surviving seven rats 7 days later to allow acute inflammation resolution. Nine transcutaneous bowel wall SWV measurements were obtained from the colon in all rats without and with applied strain. Mean SWVs without and with applied strain were compared between animal cohorts by using the Student t test, and receiver operating characteristic (ROC) curves were created to assess diagnostic performance.
resultsMean bowel wall SWVs were significantly higher for fibrotic versus acute inflammation cohort of rats at 0% (3.4 ± 1.1 vs 2.3 ± 0.5 m/sec; P = .047) and 30% (6.3 ± 2.2 vs 3.6 ± 0.9 m/sec; P = .02) applied strain. Both acute inflammation and fibrotic cohort of rats demonstrated linear increases in mean SWV with increasing applied strain, with significantly different mean slopes (P = .02) and y-intercepts (P = .02). The area under the ROC curve of the SWV ratio (mean SWV/applied strain) for differentiating histopathologically confirmed fibrotic from inflamed bowel was 0.971.
conclusionBowel wall SWV helps distinguish acutely inflamed from fibrotic intestine in a Crohn disease animal model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.