ArticleProceedings of the National Academy of Sciences of the United States of America2013
Chicken hemogen homolog is involved in the chicken-specific sex-determining mechanism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- GWAS-Identified SNPs and Candidate Genes Influencing Sex in Loach (Animals : an open access journal from MDPI · 2026Article
- Single-nucleus transcriptional and chromatin accessible profiles reveal critical cell types and molecular architecture underlying chicken sex determination.Journal of advanced research · 2025Article
- Article
- Review
- Gene Expression Profiling Reveals Potential Players of Sex Determination and Asymmetrical Development in Chicken Embryo Gonads.International journal of molecular sciences · 2023Article
- Overview of Avian Sex Reversal.International journal of molecular sciences · 2023Review
- DMRT1-mediated regulation of TOX3 modulates expansion of the gonadal steroidogenic cell lineage in the chicken embryo.Development (Cambridge, England) · 2023Article
- Review
- Highly sensitive and quick in ovo sexing of domestic chicken eggs by two-wavelength fluorescence spectroscopy.Analytical and bioanalytical chemistry · 2023Article
- Avian Sex Determination: A Chicken and Egg Conundrum.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2023Review
- The Male-Biased Expression of miR-2954 Is Involved in the Male Pathway of Chicken Sex Differentiation.Cells · 2022Article
- Prediction of sex-determination mechanisms in avian primordial germ cells using RNA-seq analysis.Scientific reports · 2022Article
- The m6A methylation regulates gonadal sex differentiation in chicken embryo.Journal of animal science and biotechnology · 2022Article
- Genetic Regulation of Avian Testis Development.Genes · 2021Review
- Expression profiling of sexually dimorphic genes in the Japanese quail, Coturnix japonica.Scientific reports · 2020Article
- Comparison of sex determination mechanism of germ cells between birds and fish: Cloning and expression analyses of chicken forkhead box L3-like gene.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken.Scientific reports · 2019Article
- DivergentBiology open · 2018Article
- Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads.Journal of the Royal Society, Interface · 2018Article
- Unique XCI evolution in Tokudaia: initial XCI of the neo-X chromosome in Tokudaia muenninki and function loss of XIST in Tokudaia osimensis.Chromosoma · 2017Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Using a comprehensive transcriptome analysis, a Z chromosome-linked chicken homolog of hemogen (cHEMGN) was identified and shown to be specifically involved in testis differentiation in early chicken embryos. Hemogen [Hemgn in mice, EDAG (erythroid differentiation-associated gene protein) in humans] was recently characterized as a hematopoietic tissue-specific gene encoding a transcription factor that regulates the proliferation and differentiation of hematopoietic cells in mammals. In chicken, cHEMGN was expressed not only in hematopoietic tissues but also in the early embryonic gonad of male chickens. The male-specific expression was identified in the nucleus of (pre)Sertoli cells after the sex determination period and before the expression of SOX9 (SRY-box 9). The expression of cHEMGN was induced in ZW embryonic gonads that were masculinized by aromatase inhibitor treatment. ZW embryos overexpressing cHEMGN, generated by infection with retrovirus carrying cHEMGN, showed masculinized gonads. These findings suggest that cHEMGN is a transcription factor specifically involved in chicken sex determination.
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