Evidence map›Paper›PMID 23401541›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2013

Reversal of age-related neural timing delays with training.

Samira Anderson, Travis White-Schwoch, Alexandra Parbery-Clark, Nina Kraus

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02147847 (Neurological Treatment to Improve the Hearing in Noise Abilities of Older Adults With Hearing Impairments.), which is not on this map. Cited by 120 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02147847 nacompletednot on this mapstarted 2015, after this paper: background citation

Neurological Treatment to Improve the Hearing in Noise Abilities of Older Adults With Hearing Impairments.

TypeinterventionalSponsorMassachusetts Eye and Ear InfirmaryRan2015 to 2016Enrolled36ConditionsPresbycusisArmsVideo game based training 1, Video game based training 2
3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
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  8. Rate Discrimination Training May Partially Restore Temporal Processing Abilities from Age-Related Deficits.Journal of the Association for Research in Otolaryngology : JARO · 2022
    Trial
  9. Trial
  10. Neural and behavioral changes after the use of hearing aids.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018
    Trial
  11. Music enrichment programs improve the neural encoding of speech in at-risk children.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Trial
  12. Trial
  13. Trial
  14. Article
  15. Observational
  16. Review
  17. Article
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  20. Neural and Behavioral Changes in Older Adults from Auditory-Cognitive Training.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samira AndersonAuditory Neuroscience Laboratory, Department of Communication Sciences, Northwestern University, Evanston, IL 60208, USA.
Travis White-Schwoch
Alexandra Parbery-Clark
Nina Kraus

Funding

Neural correlates of auditory function and training in older adultsR01DC010016 · NIDCD · NORTHWESTERN UNIVERSITY · PI DHAR, SUMITRAJIT, KRAUS, NINA · 2010 to 2014
$1.7M
Translational Research in Communication Sciences & DisordersT32DC009399 · NIDCD · NORTHWESTERN UNIVERSITY · PI LARSON, CHARLES R · 2009 to 2013
$1.6M
NIDCD NIH HHS R01 DC010016NIDCD NIH HHS R01 DC10016NIDCD NIH HHS T32 DC009399NIDCD NIH HHS T32 DC009399-01A10
6 · The paper itself

Abstract

Neural slowing is commonly noted in older adults, with consequences for sensory, motor, and cognitive domains. One of the deleterious effects of neural slowing is impairment of temporal resolution; older adults, therefore, have reduced ability to process the rapid events that characterize speech, especially in noisy environments. Although hearing aids provide increased audibility, they cannot compensate for deficits in auditory temporal processing. Auditory training may provide a strategy to address these deficits. To that end, we evaluated the effects of auditory-based cognitive training on the temporal precision of subcortical processing of speech in noise. After training, older adults exhibited faster neural timing and experienced gains in memory, speed of processing, and speech-in-noise perception, whereas a matched control group showed no changes. Training was also associated with decreased variability of brainstem response peaks, suggesting a decrease in temporal jitter in response to a speech signal. These results demonstrate that auditory-based cognitive training can partially restore age-related deficits in temporal processing in the brain; this plasticity in turn promotes better cognitive and perceptual skills.

Indexed as

AgedAgingCognitionEvoked Potentials, Auditory, Brain StemFemaleHumansMaleMemoryMiddle AgedSound LocalizationSpeech Perception

Identifiers

PMID23401541
PMCPMC3600492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.