ReviewObesity (Silver Spring, Md.)2013
Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology.
Review in Obesity (Silver Spring, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Evaluation of Metabolic Syndrome and Its Associated Risk Factors in Type 2 Diabetes: A Descriptive Cross-Sectional Study at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.BioMed research international · 2019Trial
- Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study.PloS one · 2017Trial
- Regulatory Roles of MicroRNAs in the Pathogenesis of Metabolic Syndrome.Molecular biotechnology · 2024Review
- Beyond Obesity and Overweight: the Clinical Assessment and Treatment of Excess Body Fat In Children : Part 2 - the Prescription of Low-Carbohydrate Eating as the First Approach.Current obesity reports · 2024Review
- The fructose survival hypothesis for obesity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?The American journal of clinical nutrition · 2023Review
- Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women.Frontiers in physiology · 2022Article
- Fructose and Uric Acid as Drivers of a Hyperactive Foraging Response: A Clue to Behavioral Disorders Associated with Impulsivity or Mania?Evolution and human behavior : official journal of the Human Behavior and Evolution Society · 2021Article
- Nutritional and lifestyle intervention strategies for metabolic syndrome in Southeast Asia: A scoping review of recent evidence.PloS one · 2021Article
- Body Protein Sparing in Hibernators: A Source for Biomedical Innovation.Frontiers in physiology · 2021Review
- Development and Validation of a Risk Model for Breast Cancer-Related Lymphedema.JAMA network open · 2020Article
- Effect of Supplementation with Hydroethanolic Extract ofMolecules (Basel, Switzerland) · 2020Article
- Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease.Frontiers in aging neuroscience · 2020Article
- Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review.Journal of advanced research · 2017Review
- Expression of Metabolic Syndrome in Women with Severe Obesity.Metabolic syndrome and related disorders · 2017Article
- Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes.Advances in nutrition (Bethesda, Md.) · 2017Review
- Obesity Epidemiology Worldwide.Gastroenterology clinics of North America · 2016Review
- Photoperiod induced obesity in the Brandt's vole (Lasiopodomys brandtii): a model of 'healthy obesity'?Disease models & mechanisms · 2016Article
- Inflammation Modifies the Paradoxical Association between Body Mass Index and Mortality in Hemodialysis Patients.Journal of the American Society of Nephrology : JASN · 2016Article
- Uric acid in metabolic syndrome: From an innocent bystander to a central player.European journal of internal medicine · 2016Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveThe metabolic syndrome refers to a constellation of signs including abdominal obesity, elevated serum triglycerides, low HDL-cholesterol, elevated blood pressure, and insulin resistance. Today approximately one third of the adult population has the metabolic syndrome. While there is little doubt that the signs constituting the metabolic syndrome frequently cluster, much controversy exists over the definition, pathogenesis, or clinical utility. DESIGN AND
methodsHere we present evidence from the field of comparative physiology that the metabolic syndrome is similar to the biological process that animals engage to store fat in preparation for periods of food shortage.
resultsWe propose that the metabolic syndrome be changed to fat storage condition to more clearly align with its etiology. Obesity in humans is likely the consequences of both genetic predisposition (driven in part by thrifty genes) and environment. Recent studies suggest that the loss of the uricase gene may be one factor that predisposes humans to obesity today.
conclusionUnderstanding the process animals engage to switch from a lean insulin-sensitive to an obese insulin-resistant state may provide novel insights into the cause of obesity and diabetes in humans, and unique opportunities for reversing their pathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.