ArticleMagnetic resonance in medicine2014
Principal component analysis enhances SNR for dynamic electron paramagnetic resonance oxygen imaging of cycling hypoxia in vivo.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- The Challenges of OInternational journal of molecular sciences · 2022Review
- Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms.International journal of molecular sciences · 2021Review
- EPR Everywhere.Applied magnetic resonance · 2021Review
- Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer.Cancers · 2020Review
- Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor-A Literature Review.International journal of molecular sciences · 2020Review
- Deep learning improves contrast in low-fluence photoacoustic imaging.Biomedical optics express · 2020Article
- Fractalkine/CX3CL1 in Neoplastic Processes.International journal of molecular sciences · 2020Review
- Photoacoustic Signal Enhancement: Towards Utilization of Low Energy Laser Diodes in Real-Time Photoacoustic Imaging.Sensors (Basel, Switzerland) · 2018Article
- In vivo preclinical cancer and tissue engineering applications of absolute oxygen imaging using pulse EPR.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Review
- Fast dynamic electron paramagnetic resonance (EPR) oxygen imaging using low-rank tensors.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Article
- Maximally spaced projection sequencing in electron paramagnetic resonance imaging.Concepts in magnetic resonance. Part B, Magnetic resonance engineering · 2015Article
- Real-Time Image Reconstruction for Pulse EPR Oxygen Imaging Using a GPU and Lookup Table Parameter Fitting.Concepts in magnetic resonance. Part B, Magnetic resonance engineering · 2015Article
- Implementation of GPU-accelerated back projection for EPR imaging.Journal of X-ray science and technology · 2015Article
- Comparison of parabolic filtration methods for 3D filtered back projection in pulsed EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Clinical oxygen enhancement ratio of tumors in carbon ion radiotherapy: the influence of local oxygenation changes.Journal of radiation research · 2014Article
- Compressed sensing of spatial electron paramagnetic resonance imaging.Magnetic resonance in medicine · 2014Article
- EPR image based oxygen movies for transient hypoxia.Advances in experimental medicine and biology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeLow oxygen concentration (hypoxia) in tumors strongly affects their malignant state and resistance to therapy. These effects may be more deleterious in regions undergoing cycling hypoxia. Electron paramagnetic resonance imaging (EPRI) has provided a noninvasive, quantitative imaging modality to investigate static pO2 in vivo. However, to image changing hypoxia, EPRI images with better temporal resolution may be required. The tradeoff between temporal resolution and signal-to-noise ratio (SNR) results in lower SNR for EPRI images with imaging time short enough to resolve cycling hypoxia.
methodsPrincipal component analysis allows for accelerated image acquisition with acceptable SNR by filtering noise in projection data, from which pO2 images are reconstructed. Principal component analysis is used as a denoising technique by including only low-order components to approximate the EPRI projection data.
resultsSimulated and experimental studies show that principal component analysis filtering increases SNR, particularly for small numbers of sub-volumes with changing pO2 , enabling an order of magnitude increase in temporal resolution with minimal deterioration in spatial resolution or image quality.
conclusionThe SNR necessary for dynamic EPRI studies with temporal resolution required to investigate cycling hypoxia and its physiological implications is enabled by principal component analysis filtering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.