ArticleAmerican journal of medical genetics. Part A2013
Preconception folic acid supplementation and risk for chromosome 21 nondisjunction: a report from the National Down Syndrome Project.
Article in American journal of medical genetics. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis.Molecular biology reports · 2014Pooled it
- The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis.Nutrients · 2013Pooled it
- Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands.BMC pregnancy and childbirth · 2014Trial
- Uncovering the hidden hunger in translational research for periconceptional folic acid awareness among health care providers.Journal of family medicine and primary care · 2025Article
- Specific Birth Defects Following Antiseizure Medications Used By Pregnant Women With Epilepsy.Neurology. Clinical practice · 2024Article
- Mothers of children with Down syndrome: a clinical and epidemiological study.Journal of community genetics · 2023Article
- One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome.Human cell · 2021Article
- Article
- Altered Folate Homeostasis in Children with Down Syndrome: A Potential Basis for Enhanced Methotrexate Toxicity.The Journal of pediatrics · 2020Article
- Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case-control study.Autism research : official journal of the International Society for Autism Research · 2019Article
- Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility.Cellular and molecular life sciences : CMLS · 2016Review
- Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.Human genetics · 2016Article
- The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects.Frontiers in genetics · 2015Review
- Folic acid supplementation in pregnancy and implications in health and disease.Journal of biomedical science · 2014Review
- Methylenetetrahydrofolatereductase C677T polymorphism and folate metabolism in human health.Indian journal of human genetics · 2014Article
- The association of low socioeconomic status and the risk of having a child with Down syndrome: a report from the National Down Syndrome Project.Genetics in medicine : official journal of the American College of Medical Genetics · 2013Article
- Role of folate metabolizing genes and homocysteine in mothers of Down syndrome children.Tzu chi medical journalArticle
- The impact of folic acid supplementation on gestational and long term health: Critical temporal windows, benefits and risks.Porto biomedical journalReview
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
Both a lack of maternal folic acid supplementation and the presence of genetic variants that reduce enzyme activity in folate pathway genes have been linked to meiotic nondisjunction of chromosome 21; however, the findings in this area of research have been inconsistent. To better understand these inconsistencies, we asked whether maternal use of a folic acid-containing supplement before conception reduces risk for chromosome 21 nondisjunction. Using questionnaire data from the National Down Syndrome Project, a population-based case-control study, we compared the use of folic acid-containing supplements among mothers of infants with full trisomy 21 due to maternal nondisjunction (n = 702) and mothers of infants born with no major birth defects (n = 983). Using logistic regression, adjusting for maternal age, race/ethnicity, and infant age at maternal interview, we found no evidence of an association between lack of folic acid supplementation and maternal nondisjunction among all case mothers (OR = 1.16; 95% CI: 0.90-1.48). In analyses stratified by meiotic stage and maternal age (<35 or ≥35 years), we found an association among older mothers experiencing meiosis II nondisjunction errors (OR = 2.00; 95% CI: 1.08-3.71). These data suggest that lack of folic acid supplementation may be associated specifically with MII errors in the aging oocyte. If confirmed, these results could account for inconsistencies among previous studies, as each study sample may vary by maternal age structure and proportion of meiotic errors.
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Registered trials
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