Evidence map›Paper›PMID 23400808›Full record

ReviewCurrent psychiatry reports2013

Impaired GABAergic neurotransmission in schizophrenia underlies impairments in cortical gamma band oscillations.

James M McNally, Robert W McCarley, Ritchie E Brown

Open access · greenAbstract readReview
In one paragraph

Review in Current psychiatry reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential.The international journal of neuropsychopharmacology · 2023
    Review
  8. Article
  9. Review
  10. Hippocampal circuit dysfunction in psychosis.Translational psychiatry · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Consequences of acute NaNeurotoxicology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

James M McNallyLaboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, 940 Belmont St., Research 151C, Brockton, MA, USA. james_mcnally@hms.harvard.edu
Robert W McCarley
Ritchie E Brown
VA Boston Healthcare System · USHarvard University · US

Funding

NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIAR01MH040799 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MCCARLEY, ROBERT W · 1986 to 2011
$6.5M
THE SYNAPTIC BASIS OF SLEEP CYCLE CONTROLR01MH039683 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BROWN, RITCHIE EDWARD · 1985 to 2017
$3.8M
THE SYNAPTIC BASIS OF SLEEP CYCLE CONTROLR37MH039683 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MCCARLEY, ROBERT W · 1987 to 2006
$3.1M
Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67R21MH094803 · NIMH · HARVARD MEDICAL SCHOOL · PI BROWN, RITCHIE EDWARD · 2011 to 2012
$354k
Sleep Spindles: Role of Thalamic Reticular Nucleus and Parvalbumin GABA NeuronsI01BX001356 · VA · VA BOSTON HEALTH CARE SYSTEM · PI BROWN, RITCHIE EDWARD · 2012 to 2020
–
BLRD VA I01 BX001356NIMH NIH HHS MH039683NIMH NIH HHS MH040799NIMH NIH HHS MH094803NIMH NIH HHS R01 MH039683NIMH NIH HHS R01 MH040799NIMH NIH HHS R21 MH094803NIMH NIH HHS R37 MH039683
6 · The paper itself

Abstract

Impairment of cortical circuit function is increasingly believed to be central to the pathophysiology of schizophrenia (Sz). Such impairments are suggested to result in abnormal gamma band oscillatory activity observed in Sz patients, and likely underlie the psychosis and cognitive deficits linked to this disease. Development of improved therapeutic strategies to enhance functional outcome of Sz patients is contingent upon a detailed understanding of the mechanisms behind cortical circuit development and maintenance. Convergent evidence from both Sz clinical and preclinical studies suggests impaired activity of a particular subclass of interneuron which expresses the calcium binding protein parvalbumin is central to the cortical circuit impairment observed. Here we review our current understanding of the Sz related cortical circuit dysfunction with a particular focus on the role of fast spiking parvalbumin interneurons in both normal cortical circuit activity and in NMDA receptor hypofunction models of the Sz disease state.

Indexed as

Action PotentialsCerebral CortexGABAergic NeuronsHumansSchizophreniaSynaptic Transmission

Identifiers

PMID23400808
PMCPMC3595504
OpenAlexW2052612819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.