Evidence map›Paper›PMID 23400770›Full record

ArticleRheumatology international2013

Folate usage in MTX-treated juvenile idiopathic arthritis (JIA) patients is inconsistent and highly variable.

Gil Amarilyo, Gil Amarlilyo, Ornella J Rullo, Deborah K McCurdy, Jennifer M P Woo, Daniel E Furst

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Rheumatology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Review
  3. [Uveitis in juvenile idiopathic arthritis].Zeitschrift fur Rheumatologie · 2017
    Article
4 · The record

Corrections and comments

  • Erratum issued
    Amarlilyo, Gil [corrected to Amarilyo, Gil]
5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gil AmarilyoDepartment of Pediatric Rheumatology, University of California, Los Angeles, 10833 Le Conte Avenue, MDCC 12-430, Los Angeles, CA 90095, USA. gamarilyo@tlvmc.gov.il
Gil AmarlilyoDepartment of Pediatric Rheumatology, University of California, Los Angeles, 10833 Le Conte Avenue, MDCC 12-430, Los Angeles, CA 90095, USA. gamarilyo@tlvmc.gov.il
Ornella J Rullo
Deborah K McCurdy
Jennifer M P Woo
Daniel E Furst
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Folate supplementation is widely accepted and utilized for the prevention of adverse events in juvenile idiopathic arthritis (JIA) patients who are treated with methotrexate. Despite the widespread use of folate supplementation, there is a lack of convincing evidence to support the role of folate in the enhancement of methotrexate efficacy and the prevention of methotrexate-related adverse events. In order to understand current practices used by experts, we surveyed 214 pediatric rheumatologists around the globe. Seventy-one unique folate supplementation regimens were reported for this study. Results indicated that folate supplementation (either in the form of folic acid or folinic acid) is inconsistent and highly variable within the United States as well as between the United States and other countries. This level of variability is often associated with lack of evidence and emphasizes the need for well-designed clinical trials to support a rational folate supplementation regimen in patients with JIA who are treated with methotrexate.

Indexed as

AdolescentAdultArthritis, JuvenileChildDietary SupplementsFolic AcidHumansLeucovorinMethotrexateFolic AcidLeucovorinMethotrexate

Identifiers

PMID23400770
OpenAlexW2125201397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.