Evidence map›Paper›PMID 23400701›Full record

ArticleBeilstein journal of organic chemistry2013

Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors.

Francesca Pertici, Norbert Varga, Arnoud van Duijn, Matias Rey-Carrizo, Anna Bernardi, Roland J Pieters

Abstract read
In one paragraph

Article in Beilstein journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Ultrafast Excited-State Dynamics of a Porphyrin-OPE Conjugate: Energy Transfer and Aggregation Effects.The journal of physical chemistry. C, Nanomaterials and interfaces · 2025
    Article
  2. A Portrait of the OPE as a Biological Agent.Molecules (Basel, Switzerland) · 2021
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Synthesis of rigid p-terphenyl-linked carbohydrate mimetics.Beilstein journal of organic chemistry · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca PerticiDepartment of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
Norbert Varga
Arnoud van Duijn
Matias Rey-Carrizo
Anna Bernardi
Roland J Pieters

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of phenylene-ethynylene rods and their use as rigid spacers is described. Alternation of a Sonogashira reaction and silyl group cleavage was used to obtain rigid spacers with even and odd numbers of phenylene units. Preliminary applications of these rods in divalent systems are shown. Inhibition studies with Pseudomonas Aeruginosa lectin LecA showed that the rigid spacer proved greatly beneficial for the inhibitory potency.

Indexed as

LecA inhibitionmultivalent carbohydratesphenylene ethynylenerigid spacersSonogashira reaction

Identifiers

PMID23400701
PMCPMC3566787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.