Evidence map›Paper›PMID 23400429›Full record

ArticleBeilstein journal of organic chemistry2013

From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies.

Kevin S Martin, Cristian Soldi, Kellan N Candee, Hiromi I Wettersten, Robert H Weiss, Jared T Shaw

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kevin S MartinDepartment of Chemistry, University of California, Davis, CA 95616, USA ; Comparative Pathology Graduate Group, University of California, Davis, CA 95616, USA.
Cristian Soldi
Kellan N Candee
Hiromi I Wettersten
Robert H Weiss
Jared T Shaw

Funding

Metabolomic discovery and validation of urinary biomarkers for kidney cancerR01CA135401 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WEISS, ROBERT H. · 2009 to 2013
$1.5M
Complex Heterocycles and Hybrid Strategies for Pilot Scale LibrariesP41GM089153 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KURTH, MARK J. · 2010 to 2012
$1.1M
A Metabolomic Approach to Discovering Biomarkers for ADPKDR01DK082690 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WEISS, ROBERT H. · 2009 to 2010
$696k
NCI NIH HHS R01 CA135401NIDDK NIH HHS R01 DK082690NIGMS NIH HHS P41 GM089153
6 · The paper itself

Abstract

A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a "one-bead, one-compound" combinatorial approach for on-bead screening purposes. The current synthesis is carried out in solution and is amenable to scale-up for follow-up studies on LLW62 and investigations of related structures. The key step involves the use of a β-amino acid-forming three-component reaction (3CR), the scope of which defines its role in the synthetic strategy.

Indexed as

benzimidazolemulticomponent reactionβ-amino acid

Identifiers

PMID23400429
PMCPMC3566855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.