ReviewJournal of molecular evolution2013
Three independent determinants of protein evolutionary rate.
Review in Journal of molecular evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Translating functional molecular knowledge into crop-breeding success.Nature reviews. Genetics · 2026Review
- Genomic insights into positive selection during barley domestication.BMC plant biology · 2022Article
- Protein Complexes Form a Basis for Complex Hybrid Incompatibility.Frontiers in genetics · 2021Review
- Correlates of evolutionary rates in the murine sperm proteome.BMC evolutionary biology · 2018Article
- Molecular Evolutionary Constraints that Determine the Avirulence State of Clostridium botulinum C2 Toxin.Journal of molecular evolution · 2017Article
- Essentiality Is a Strong Determinant of Protein Rates of Evolution during Mutation Accumulation Experiments in Escherichia coli.Genome biology and evolution · 2016Article
- Population transcriptomics uncovers the regulation of gene expression variation in adaptation to changing environment.Scientific reports · 2016Article
- The organelle of differentiation in embryos: the cell state splitter.Theoretical biology & medical modelling · 2016Review
- ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1.BMC evolutionary biology · 2015Article
- Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymes.Journal of the Royal Society, Interface · 2015Review
- Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism.DNA repair · 2014Article
- Highly variable recombinational landscape modulates efficacy of natural selection in birds.Genome biology and evolution · 2014Article
- Determinants of expression variability.Nucleic acids research · 2014Article
- Linking molecular evolution to molecular grafting.The Journal of biological chemistryReview
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Authors and funding
2 authors.
Funding
Abstract
One of the most widely accepted ideas related to the evolutionary rates of proteins is that functionally important residues or regions evolve slower than other regions, a reasonable outcome of which should be a slower evolutionary rate of the proteins with a higher density of functionally important sites. Oddly, the role of functional importance, mainly measured by essentiality, in determining evolutionary rate has been challenged in recent studies. Several variables other than protein essentiality, such as expression level, gene compactness, protein-protein interactions, etc., have been suggested to affect protein evolutionary rate. In the present review, we try to refine the concept of functional importance of a gene, and consider three factors-functional importance, expression level, and gene compactness, as independent determinants of evolutionary rate of a protein, based not only on their known correlation with evolutionary rate but also on a reasonable mechanistic model. We suggest a framework based on these mechanistic models to correctly interpret the correlations between evolutionary rates and the various variables as well as the interrelationships among the variables.
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Registered trials
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