ArticleFrontiers in biology2013
Alternative splicing switching in stem cell lineages.
Article in Frontiers in biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- RBFOX2-dependent alternative splicing of Numb regulates Notch signaling during muscle stem cell activation.Stem cell reports · 2026Article
- Proteomic landscape of porcine induced neural stem cell reprogramming and differentiation.PeerJ · 2025Article
- Co-expression of PADI isoforms during progenitor differentiation enables functional diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Transcription factors and splice factors - interconnected regulators of stem cell differentiation.Current stem cell reports · 2023Article
- LncRNAs and their RBPs: How to influence the fate of stem cells?Stem cell research & therapy · 2022Review
- Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes.BMC genomics · 2022Article
- Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress.PLoS genetics · 2021Article
- Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing.Cell death and differentiation · 2017Article
- Upregulation of RNA Processing Factors in Poorly Differentiated Lung Cancer Cells.Translational oncology · 2016Article
- RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells.Molecular vision · 2016Article
- Regulation of alternative splicing at the single-cell level.Molecular systems biology · 2015Article
- Novel transcription factor variants through RNA-sequencing: the importance of being "alternative".International journal of molecular sciences · 2015Article
- Alternative splicing acting as a bridge in evolution.Stem cell investigation · 2015Article
- Microenvironmental regulation of telomerase isoforms in human embryonic stem cells.Stem cells and development · 2014Article
- Role of Pnn in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.Molecular vision · 2014Article
- Asymmetric distribution of histones during Drosophila male germline stem cell asymmetric divisions.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
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Authors and funding
2 authors.
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Abstract
The application of stem cells to regenerative medicine depends on a thorough understanding of the molecular mechanisms underlying their pluripotency. Many studies have identified key transcription factor-regulated transcriptional networks and chromatin landscapes of embryonic and a number of adult stem cells. In addition, recent publications have revealed another interesting molecular feature of stem cells- a distinct alternative splicing pattern. Thus, it is possible that both the identity and activity of stem cells are maintained by stem cell-specific mRNA isoforms, while switching to different isoforms ensures proper differentiation. In this review, we will discuss the generality of mRNA isoform switching and its interaction with other molecular mechanisms to regulate stem cell pluripotency, as well as the reprogramming process in which differentiated cells are induced to become pluripotent stem cell-like cells (iPSCs).
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