Evidence map›Paper›PMID 23399972›Full record

ReviewNature reviews. Cardiology2013

Assessment and management of blood-pressure variability.

Gianfranco Parati, Juan E Ochoa, Carolina Lombardi, Grzegorz Bilo

Erratum issued 3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 413 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
413citing papers in PubMed, 8 pooled it
31.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02499822 phase4completednot on this mapstarted 2015, after this paper: background citation

Short - Medium and Long Term Blood Pressure Variability in Essential Hypertensive Patients Treated With Nifedipine GITS or Ramipril - a Randomized Trial

TypeinterventionalSponsorIstituto Auxologico ItalianoRan2015 to 2020Enrolled168ConditionsHypertension, High Blood Pressure VariabilityArmsNifedipine GITS, Ramipril
NCT04681612 unknown statusnot on this mapstarted 2019, after this paper: background citation

The Prognostic Role of Indices of Sympathetic Nervous System Overdrive in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries

Typeobservational_patient_registrySponsorHippocration General HospitalRan2019 to 2023Enrolled150ConditionsMyocardial Infarction With Nonobstructive Coronary ArteriesArmsMSNA, Heart Rate Variability, Blood Pressure Variability, CMR, History, Lab, clinical and hemodynamic parameters
NCT05438446 phase2completednot on this mapstarted 2021, after this paper: background citation

Effect of Renal Denervation on Stress, Hypertension and Anxiety Management (ERSHAM Study) in Patients With Uncontrolled Hypertension

TypeinterventionalSponsorHippocration General HospitalRan2021 to 2026Enrolled60ConditionsHypertension Arterial, Anxiety, StressArmsEndovascular ultrasound renal denervation (Paradise renal denervation system, ReCor, CA, USA) (RDN)
3 · Its place in the literature

Who cites it

413 citing papers in PubMed, 8 syntheses or guidelines pooled it, 830 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. A Systematic Review of Publications on the Associations Between Sleep Architecture and Arterial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

353 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gianfranco ParatiDepartment of Cardiology, S. Luca Hospital, IRCCS, Istituto Auxologico Italiano & University of Milano-Bicocca Piazza Brescia 20, Milan 20149, Italy. gianfranco.parati@ unimib.it
Juan E Ochoa
Carolina Lombardi
Grzegorz Bilo
IRCCS Istituto Auxologico Italiano · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood pressure (BP) is characterized by marked short-term fluctuations occurring within a 24 h period (beat-to-beat, minute-to-minute, hour-to-hour, and day-to-night changes) and also by long-term fluctuations occurring over more-prolonged periods of time (days, weeks, months, seasons, and even years). Rather than representing 'background noise' or a randomly occurring phenomenon, these variations have been shown to be the result of complex interactions between extrinsic environmental and behavioural factors and intrinsic cardiovascular regulatory mechanisms. Although the adverse cardiovascular consequences of hypertension largely depend on absolute BP values, evidence from observational studies and post-hoc analyses of data from clinical trials have indicated that these outcomes might also depend on increased BP variability (BPV). Increased short-term and long-term BPV are associated with the development, progression, and severity of cardiac, vascular, and renal damage and with an increased risk of cardiovascular events and mortality. Of particular interest are the findings from post-hoc analyses of large intervention trials in hypertension, showing that within-patient visit-to-visit BPV is strongly prognostic for cardiovascular morbidity and mortality. This result has prompted discussion on whether antihypertensive treatment should be targeted not only towards reducing mean BP levels but also to stabilizing BPV with the aim of achieving consistent BP control over time, which might favour cardiovascular protection.

Indexed as

Blood Pressure DeterminationAntihypertensive AgentsBlood PressureDisease ProgressionHumansHypertensionPredictive Value of TestsRisk FactorsTime FactorsTreatment OutcomeAntihypertensive Agents

Identifiers

PMID23399972
OpenAlexW1988381397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.