ArticleExperimental neurology2013
The temporal pattern of stimulation may be important to the mechanism of deep brain stimulation.
Article in Experimental neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07213999 (Evaluating and Understanding the Effects of Deep Brain Stimulation Using Novel Electrophysiology Technique and Device in Parkinson's Disease), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating and Understanding the Effects of Deep Brain Stimulation Using Novel Electrophysiology Technique and Device in Parkinson's Disease
Who cites it
22 citing papers in PubMed, 87 citations in OpenAlex.
- Computer-Guided Deep Brain Stimulation Programming for Parkinson's Disease.Neuromodulation : journal of the International Neuromodulation Society · 2016Trial
- Long-term treatment with responsive brain stimulation in adults with refractory partial seizures.Neurology · 2015Trial
- Trial
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- A bioelectric router for adaptive isochronous neurostimulation enables multipolar bioelectric stimulation from a single source.Scientific reports · 2025Article
- Seizure freedom using a regional approach to responsive neurostimulation for multifocal drug-resistant epilepsy: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Machine learning for adaptive deep brain stimulation in Parkinson's disease: closing the loop.Journal of neurology · 2023Review
- Deep brain-machine interfaces: sensing and modulating the human deep brain.National science review · 2022Review
- Excitatory deep brain stimulation quenches beta oscillations arising in a computational model of the subthalamo-pallidal loop.Scientific reports · 2022Article
- The cortical evoked potential corresponds with deep brain stimulation efficacy in rats.Journal of neurophysiology · 2022Article
- Adjust Neuronal Reactions to Pulses of High-Frequency Stimulation with Designed Inter-Pulse-Intervals in Rat Hippocampus In Vivo.Brain sciences · 2021Article
- Small Changes in Inter-Pulse-Intervals Can Cause Synchronized Neuronal Firing During High-Frequency Stimulations in Rat Hippocampus.Frontiers in neuroscience · 2019Article
- Temporal Pattern of Electrical Stimulation is a New Dimension of Therapeutic Innovation.Current opinion in biomedical engineering · 2018Article
- Design of a novel stimulation system with time-varying paradigms for investigating new modes of high frequency stimulation in brain.Biomedical engineering online · 2018Article
- Advances in closed-loop deep brain stimulation devices.Journal of neuroengineering and rehabilitation · 2017Review
- Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation.Journal of neurophysiology · 2016Article
- Computational modeling to improve treatments for essential tremor.Drug discovery today. Disease models · 2016Article
- The effects of subthalamic deep brain stimulation on mechanical and thermal thresholds in 6OHDA-lesioned rats.The European journal of neuroscience · 2015Article
- A novel combinational approach of microstimulation and bioluminescence imaging to study the mechanisms of action of cerebral electrical stimulation in mice.The Journal of physiology · 2015Article
- Motion sensor strategies for automated optimization of deep brain stimulation in Parkinson's disease.Parkinsonism & related disorders · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Deep brain stimulation (DBS) has emerged as an important and potentially powerful treatment option for the management of carefully selected patients with advanced Parkinson's disease (PD) who are not adequately controlled by standard medication therapy. Though considerable advances have been made, the mechanisms underlying the therapeutic effects of DBS remain unclear despite its clinical efficacy. It is now widely held that both excitation and inhibition can occur secondary to stimulation, and it is suspected that abnormal synchronized oscillations may also be important in the mechanism of DBS. Other potentially important processes, including blood flow changes, local and upstream neurogenesis, and the modulation of neurotransmitters through stimulation of bordering astrocytes are also being investigated. Recent research has suggested that the temporal pattern of DBS stimulation is also an important variable in DBS neuromodulation, yet the extent of its influence on DBS efficacy has yet to be determined. As high stimulation frequency alone does not appear to be sufficient for optimal symptom suppression, attention to stimulation pattern might lead to more effective symptom control and reduced side effects, possibly at a lower frequency. Stimulation pattern may be potentially amenable to therapeutic modulation and its role in the clinical efficacy of DBS should be addressed through further focus and research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.