Evidence map›Paper›PMID 23399889›Full record

ArticleExperimental neurology2013

Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: experimental evidence.

Daniela Kuzdas, Sylvia Stemberger, Stefano Gaburro, Nadia Stefanova, Nicolas Singewald, Gregor K Wenning

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. A Mouse Model of Multiple System Atrophy: Bench to Bedside.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  8. Article
  9. Review
  10. Neurons and Glia Interplay in α-Synucleinopathies.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Models of multiple system atrophy.Experimental & molecular medicine · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daniela KuzdasDivision of Neurobiology, Department of Neurology and Neurosurgery, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Sylvia Stemberger
Stefano Gaburro
Nadia Stefanova
Nicolas Singewald
Gregor K Wenning
Innsbruck Medical University · ATUniversität Innsbruck · AT

Funding

Austrian Science Fund FWF W 1206
6 · The paper itself

Abstract

Multiple system atrophy (MSA) is a fatal, rapidly progressive neurodegenerative disease with limited symptomatic treatment options. Discrimination of MSA from other degenerative disorders crucially depends on the presence of early and severe cardiovascular autonomic failure (CAF). We have previously shown that neuropathologic lesions in the central autonomic nuclei similar to the human disease are present in transgenic MSA mice generated by targeted oligodendroglial overexpression of α-syn using the PLP promoter. We here explore whether such lesions result in abnormalities of heart rate variability (HRV) and circadian rhythmicity which are typically impaired in MSA patients. HRV analysis was performed in five month old transgenic PLP-α-syn (tg) MSA mice and age-matched wild type controls. Decreased HRV and alterations in the circadian rhythmicity were detected in the tg MSA group. The number of choline-acetyltransferase-immunoreactive neurons in the nucleus ambiguus was significantly decreased in the tg group, whereas the levels of arginine-vasopressin neurons in the suprachiasmatic and paraventricular nucleus were not affected. Our finding of impaired HRV and circadian rhythmicity in tg MSA mice associated with degeneration of the nucleus ambiguus suggests that a cardinal non-motor feature of human MSA can be reproduced in the mouse model strengthening its role as a valuable testbed for studying selective vulnerability and assessing translational therapies.

Indexed as

alpha-SynucleinAnalysis of VarianceAnimalsArginine VasopressinBody TemperatureCardiovascular AbnormalitiesCholine O-AcetyltransferaseDisease Models, AnimalElectrocardiographyElectroencephalographyHeart RateMaleMiceMice, Inbred C57BLMice, TransgenicMotor Activityalpha-SynucleinArginine VasopressinCholine O-AcetyltransferaseMyelin Proteolipid Proteinalpha-synucleinAlpha-synucleinarginine-vasopressinAutonomic failureAVPcerebellar variant of MSAChATcholine-acetyltransferaseECGelectrocardiogramGCIHeart rate variabilityHFhigh frequencyLFlow frequencymagnetic resonanceMRMSAMSA-CMSA-Pmultiple system atrophyMultiple system atrophy(oligodendro-)glial cytoplasmic inclusionsolivopontocerebellar atrophyOPCAparkinsonian variant of MSAPETPLPpositron emission tomographyproteolipid protein promoterRMSSDroot mean square of successive RR interval differencesSAOAsingle-photon emission computed tomographySNDSPECTsporadic adult onset ataxiastriatonigral degenerationtgTHtransgenicTransgenic animal modeltyrosine hydroxylaseUMSARSunified MSA rating scalewild typewtα-syn

Identifiers

PMID23399889
PMCPMC3748345
OpenAlexW2086901794

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.