Evidence map›Paper›PMID 23399822›Full record

ArticleThe Journal of investigative dermatology2013

COUP-TF-interacting protein-2 (Ctip2): driving the coupé of sphingolipid biosynthesis in the epidermis.

Wendy B Bollag

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System.Frontiers in cell and developmental biology · 2020
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Wendy B BollagCharlie Norwood VA Medical Center, Augusta, Georgia, USA; Departments of Physiology and Medicine (Dermatology), Georgia Health Sciences University, Augusta, Georgia, USA. Electronic address: wbollag@georgiahealth.edu.
Charlie Norwood VA Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies using chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (Ctip2) knockout mice have demonstrated the importance of this transcription factor for the formation of the epidermal permeability barrier. Because sphingolipids are crucial in generating the barrier, in this issue Indra and colleagues show, perhaps not surprisingly, that Ctip2 has a key role in sphingolipid metabolism. Thus, Ctip2 gene ablation alters sphingolipid levels and expression of genes encoding sphingolipid-metabolizing enzymes, in some cases by direct binding to their promoters. Abnormalities in Ctip2 could therefore underlie skin disorders characterized by an aberrant epidermal permeability barrier.

Indexed as

AnimalsEpidermisGene Expression RegulationLipid MetabolismRepressor ProteinsSkinSphingolipidsTranscription FactorsTumor Suppressor ProteinsBcl11b protein, mouseRepressor ProteinsSphingolipidsTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID23399822
OpenAlexW1984275008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.