ArticleBeilstein journal of organic chemistry2013
Peptoids and polyamines going sweet: Modular synthesis of glycosylated peptoids and polyamines using click chemistry.
Article in Beilstein journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A Peptoid Delivers CoQ-derivative to Plant Mitochondria via Endocytosis.Scientific reports · 2019Article
- Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.Molecular & cellular proteomics : MCP · 2015Article
- Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores.Beilstein journal of organic chemistry · 2014Article
- Multivalent glycosystems for nanoscience.Beilstein journal of organic chemistry · 2014Article
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7 authors.
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Abstract
Sugar moieties are present in a wide range of bioactive molecules. Thus, having versatile and fast methods for the decoration of biomimetic molecules with sugars is of fundamental importance. The glycosylation of peptoids and polyamines as examples of such biomimetic molecules is reported here. The method uses Cu-catalyzed azide alkyne cycloaddition to promote the reaction of azidosugars with either polyamines or peptoids. In addition, functionalized nucleic acids were attached to polyamines via the same route. Based on a modular solid-phase synthesis of peralkynylated peptoids with up to six alkyne groups, the latter were modified with azidosugar building blocks by using copper-catalyzed azide alkyne cycloadditions. In addition, the up-scaling of some particular azide-modified sugars is described.
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