Evidence map›Paper›PMID 23399469›Full record

ArticleBiological psychiatry2013

CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease.

Sam Gandy, Vahram Haroutunian, Steven T DeKosky, Mary Sano, Eric E Schadt

Abstract readComment
In one paragraph

Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. The Alzheimer's disease-associated complement receptor 1 variant confers risk by impacting glial phagocytosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Alzheimer mutant speeds APP transport.The Journal of experimental medicine · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Big Omics Data Experience.SC ... conference proceedings. SC (Conference : Supercomputing) · 2015
    Article
  15. CR1 in Alzheimer's disease.Molecular neurobiology · 2015
    Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sam GandyDepartment of Psychiatry and Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA. samuel.gandy@mssm.edu
Vahram Haroutunian
Steven T DeKosky
Mary Sano
Eric E Schadt

Funding

Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Milos D Ikonomovic · 2005 to 2026
$56.5M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
TAU, AB, SYNUCLEIN AND NITRATIVE/OXIDATIVE DAMAGE IN MCIP01AG014449 · NIA · UNIVERSITY OF PITTSBURGH · PI IKONOMOVIC, MILOS D · 1997 to 2024
$39.7M
VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHIMMING, CORBETT · 1985 to 2019
$37.9M
QUANTITATIVE ANALYSIS OF MICROVASCULAR CHANGES IN THE AGING BRAINP01AG002219 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI HAROUTUNIAN, VAHRAM · 1985 to 2009
$19.2M
Model for SorCS1-mediated Diabetes with DementiaR01NS075685 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GANDY, SAMUEL E. · 2012 to 2015
$1.5M
Generation and Characterization of Alzheimer Brain CellsRF1AG042965 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GANDY, SAMUEL E., NOGGLE, SCOTT ALLEN · 2012 to 2012
$516k
Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer BiologyI01BX000348 · VA · JAMES J PETERS VA MEDICAL CENTER · PI GANDY, SAMUEL E. · 2009 to 2012
–
BLRD VA I01 BX000348NIA NIH HHS AG02219NIA NIH HHS AG025204NIA NIH HHS AG042965NIA NIH HHS AG05133NIA NIH HHS AG05138NIA NIH HHS AG14449NIA NIH HHS P01 AG002219NIA NIH HHS P01 AG014449NIA NIH HHS P01 AG025204NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005138NIA NIH HHS RF1 AG042965NINDS NIH HHS NS075685NINDS NIH HHS R01 NS075685
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingAlzheimer DiseaseAmyloidApolipoproteins EBrainFemaleHumansMaleReceptors, Complement 3bAmyloidApolipoproteins EReceptors, Complement 3b

Identifiers

PMID23399469
PMCPMC3600375

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.