Evidence map›Paper›PMID 23399362›Full record

ArticleBlood transfusion = Trasfusione del sangue2014

Human neutrophil alloantigen genotype frequencies in Thai blood donors.

Khaimuk Changsri, Pussadee Tobunluepop, Dujdow Songthammawat, Teerakul Apornsuwan, Chollanot Kaset, Oytip Nathalang

Abstract read
In one paragraph

Article in Blood transfusion = Trasfusione del sangue, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Phenotyping and Genotyping of HNA: Prevalence, Risk of Alloimmunization, and HNA Incompatibilities in Indians.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023
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  11. Frequency of FCGR3B alleles in Thai blood donors.Annals of laboratory medicine · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Khaimuk ChangsriDepartment of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand.
Pussadee TobunluepopDepartment of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand.
Dujdow SongthammawatDepartment of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand.
Teerakul ApornsuwanDepartment of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand.
Chollanot KasetDepartment of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand.
Oytip NathalangDepartment of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand.
Thammasat University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibodies to human neutrophil antigens (HNA) can cause transfusion reactions, as well as autoimmune and neonatal neutropenia. This study is the first to report the frequencies of human neutrophil antigen genotypes in the Thai population. MATERIALS AND

methodsThree hundred unrelated, healthy Thai blood donors at the National Blood Centre, Thai Red Cross Society, Bangkok, Thailand were typed for HNA-1a, -1b, -1c, -3a, -3b and -4a using polymerase chain reaction with sequence-specific primers. Moreover, HNA-5a genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism.

resultsThe gene frequencies of HNA-1a, -1b and -1c were 0.470, 0.530 and 0.005, respectively. The frequencies of HNA-3a and -3b were 0.490 and 0.510, respectively. Additionally, the HNA-4a+/+ and HNA-4a+/- genotype frequencies were 0.947 and 0.053, respectively. The frequencies of HNA-5a+/+, HNA-5a+/- and HNA-5a-/- genotypes were 0.641, 0.297 and 0.062, respectively. Compared with other Asian populations, Thais have higher frequencies of HNA-1b (P<0.001). On the other hand, the frequency of HNA-5a observed in Thais is lower than that reported among Koreans (P<0.001). DISCUSSION: These findings suggest that Thais would be more susceptible to HNA-1b alloimmunisation. Furthermore, our results could establish a useful human neutrophil antigen donor file to provide more effective transfusion of blood and blood components.

Indexed as

Blood DonorsAdultGene FrequencyGenotypeHumansIsoantigensMiddle AgedNeutrophilsPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthSequence Analysis, DNAThailandYoung AdultIsoantigens

Identifiers

PMID23399362
PMCPMC3934247
OpenAlexW265539480

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.