ArticleNutrition journal2013
Associations between dietary patterns and gene expression profiles of healthy men and women: a cross-sectional study.
Article in Nutrition journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01343342 (Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors), which is not on this map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors
Who cites it
36 citing papers in PubMed.
- Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial.Mediators of inflammation · 2015Trial
- The metabolic signature associated with the Western dietary pattern: a cross-sectional study.Nutrition journal · 2013Trial
- Dietary variations drive divergent phenotypic, transcriptomic, and metatranscriptomic profiles in Biomphalaria glabrata, a schistosomiasis vector snail.Parasites & vectors · 2026Article
- Contributions of Dietary Patterns and Factors to Regulation of Rheumatoid Disease.International journal of molecular sciences · 2025Review
- Exploring the Interplay of Genetics and Nutrition in the Rising Epidemic of Obesity and Metabolic Diseases.Nutrients · 2024Review
- Diet Impacts on Gene Expression in Healthy Colon Tissue: Insights from the BarcUVa-Seq Study.Nutrients · 2024Article
- Genomes in clinical care.NPJ genomic medicine · 2024Review
- Article
- Graphical Dirichlet Process for Clustering Non-Exchangeable Grouped Data.Journal of machine learning research : JMLR · 2024Article
- Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: a position paper from the EU-CardioRNA COST action CA17129.Cardiovascular research · 2022Article
- Dietary patterns in association with the expression of pro-metastatic genes in primary breast cancer.European journal of nutrition · 2022Article
- Variation in cardiovascular disease risk factors among older adults in the Hunter Community Study cohort: A comparison of diet quality versus polygenic risk score.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Article
- Validating Accuracy of a Mobile Application against Food Frequency Questionnaire on Key Nutrients with Modern Diets for mHealth Era.Nutrients · 2022Article
- The association of animal and plant protein with successful ageing: a combined analysis of MEDIS and ATTICA epidemiological studies.Public health nutrition · 2021Article
- Colon transcriptome is modified by a dietary pattern/atorvastatin interaction in the Ossabaw pig.The Journal of nutritional biochemistry · 2021Article
- Methylomes in Vegans versus Pescatarians and Nonvegetarians.Epigenomes · 2020Article
- Review
- Plant-Based Diets for Personal, Population, and Planetary Health.Advances in nutrition (Bethesda, Md.) · 2019Article
- Review
- Mechanisms and Measurement of Changes in Gene Expression.Biological research for nursing · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundDiet regulates gene expression profiles by several mechanisms. The objective of this study was to examine gene expression in relation with dietary patterns.
methodsTwo hundred and fifty four participants from the greater Quebec City metropolitan area were recruited. Two hundred and ten participants completed the study protocol. Dietary patterns were derived from a food frequency questionnaire (FFQ) by factor analysis. For 30 participants (in fasting state), RNA was extracted from peripheral blood mononuclear cells (PBMCs) and expression levels of 47,231 mRNA transcripts were assessed using the Illumina Human-6 v3 Expression BeadChips®. Microarray data was pre-processed with Flexarray software and analysed with Ingenuity Pathway Analysis (IPA).
resultsTwo dietary patterns were identified. The Prudent dietary pattern was characterised by high intakes of vegetables, fruits, whole grain products and low intakes of refined grain products and the Western dietary pattern, by high intakes of refined grain products, desserts, sweets and processed meats. When individuals with high scores for the Prudent dietary pattern where compared to individuals with low scores, 2,083 transcripts were differentially expressed in men, 1,136 transcripts in women and 59 transcripts were overlapping in men and women. For the Western dietary pattern, 1,021 transcripts were differentially expressed in men with high versus low scores, 1,163 transcripts in women and 23 transcripts were overlapping in men and women. IPA reveals that genes differentially expressed for both patterns were present in networks related to the immune and/or inflammatory response, cancer and cardiovascular diseases.
conclusionGene expression profiles were different according to dietary patterns, which probably modulate the risk of chronic diseases.
trial registrationNCT: NCT01343342.
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