Evidence map›Paper›PMID 23398528›Full record

Trial reportJournal of internal medicine2013

Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome -- a randomized study (SYSDIET).

M Uusitupa, K Hermansen, M J Savolainen, U Schwab, M Kolehmainen, L Brader, L S Mortensen, L Cloetens, A Johansson-Persson, G Onning and 25 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04920409 (Effect of an Antiinflammatory Diet on Postprandial Gene Expression of Mononuclear Cells of Adult Obese Women), which is not on this map. Cited by 116 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 9 pooled it
27.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04920409 nacompletednot on this mapstarted 2018, after this paper: background citation

Effect of an Antiinflammatory Diet on Postprandial Gene Expression of Mononuclear Cells of Adult Obese Women

TypeinterventionalSponsorUniversidad de CaldasRan2018 to 2018Enrolled44ConditionsObesityArmsFAWGT diet, Usual diet (UD)
3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 9 syntheses or guidelines pooled it, 266 citations in OpenAlex.

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  9. Effects of total fat intake on body weight.The Cochrane database of systematic reviews · 2015
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 13 institutions in 5 countries.

M UusitupaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. matti.uusitupa@uef.fi
K Hermansen
M J Savolainen
U Schwab
M Kolehmainen
L Brader
L S Mortensen
L Cloetens
A Johansson-Persson
G Onning
M Landin-Olsson
K-H Herzig
J Hukkanen
F Rosqvist
D Iggman
J Paananen
K J Pulkki
M Siloaho
L Dragsted
T Barri
K Overvad
K E Bach Knudsen
M S Hedemann
P Arner
I Dahlman
G I A Borge
P Baardseth
S M Ulven
I Gunnarsdottir
S Jónsdóttir
I Thorsdottir
M Orešič
K S Poutanen
U Risérus
B Akesson
University of Eastern Finland · FILund University · SEUniversity of Iceland · ISAarhus University · DKAarhus University Hospital · DKUppsala University · SEKarolinska Institutet · SENofima · NOUniversity of Copenhagen · DKUniversity of Oulu · FIKuopio University Hospital · FIOsloMet – Oslo Metropolitan University · NOSkåne University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDifferent healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome.

methodsWe conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m(-2) , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids.

resultsBody weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L(-1) 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L(-1) , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra.

conclusionsHealthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.

Indexed as

DietEnergy IntakeInsulin ResistanceApolipoproteins AApolipoproteins BBiomarkersBlood GlucoseBlood PressureCholesterol, HDLCholesterol, LDLDenmarkFatty AcidsFinlandGlucose Tolerance TestHumansIcelandApolipoproteins AApolipoproteins BBiomarkersBlood GlucoseCholesterol, HDLCholesterol, LDLFatty AcidsInterleukin 1 Receptor Antagonist ProteinLipids

Identifiers

PMID23398528
PMCPMC3749468
OpenAlexW2096594628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.