ArticleStem cells and development2013
Reconstitution of the myocardium in regenerating newt hearts is preceded by transient deposition of extracellular matrix components.
Article in Stem cells and development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Regeneration of the lizard heart after cryoinjury.Experimental physiology · 2026Article
- Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice.Nature cardiovascular research · 2025Article
- Review
- Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration.Frontiers in cell and developmental biology · 2024Review
- Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart-Part I: Experimental Injury Models to Study Cardiac Regeneration.Journal of cardiovascular development and disease · 2023Review
- Innate Mechanisms of Heart Regeneration.Cold Spring Harbor perspectives in biology · 2021Review
- Identification of Novel and Potent Modulators Involved in Neonatal Cardiac Regeneration.Pediatric cardiology · 2021Article
- Nucleated red blood cells participate in myocardial regeneration in the toadExperimental biology and medicine (Maywood, N.J.) · 2021Article
- Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms.Science China. Life sciences · 2021Review
- Immunity in salamander regeneration: Where are we standing and where are we headed?Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Cellular and Molecular Mechanism of Cardiac Regeneration: A Comparison of Newts, Zebrafish, and Mammals.Biomolecules · 2020Review
- Reviewing the Limitations of Adult Mammalian Cardiac Regeneration: Noncoding RNAs as Regulators of Cardiomyogenesis.Biomolecules · 2020Review
- Model organisms at the heart of regeneration.Disease models & mechanisms · 2019Review
- Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts.Journal of cardiovascular development and disease · 2019Review
- Zebrafish heart regeneration: 15 years of discoveries.Regeneration (Oxford, England) · 2017Review
- Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape.NPJ Regenerative medicine · 2017Article
- Naturally Engineered Maturation of Cardiomyocytes.Frontiers in cell and developmental biology · 2017Review
- Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio ( Devario aequipinnatus) and Zebrafish ( Danio rerio) Hearts.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways.Cardiovascular research · 2016Article
- Mechanisms of Cardiac Regeneration.Developmental cell · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult newts efficiently regenerate the heart after injury in a process that involves proliferation of cardiac muscle and nonmuscle cells and repatterning of the myocardium. To analyze the processes that underlie heart regeneration in newts, we characterized the structural changes in the myocardium that allow regeneration after mechanical injury. We found that cardiomyocytes in the damaged ventricle mainly die by necrosis and are removed during the first week after injury, paving the way for the extension of thin myocardial trabeculae, which initially contain only very few cardiomyocytes. During the following 200 days, these thin trabeculae fill up with new cardiomyocytes until the myocardium is fully reconstituted. Interestingly, reconstruction of the newly formed trabeculated network is accompanied by transient deposition of extracellular matrix (ECM) components such as collagen III. We conclude that the ECM is a critical guidance cue for outgrowing and branching trabeculae to reconstruct the trabeculated network, which represents a hallmark of uninjured cardiac tissue in newts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.