ArticleBehavioral neuroscience2013
Neonatal hippocampal damage impairs specific food/place associations in adult macaques.
Article in Behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Review
- Safeguarding Neuronal Integrity: Unveiling Possible Role of NFκB in the Neuroprotective Efficacy of Andrographolide Contrary to Aluminium Chloride-induced Neurotoxicity and Associated Spatial Memory Impairments in Rats.Central nervous system agents in medicinal chemistry · 2025Article
- Hippocampal lesions impair non-navigational spatial memory in macaques.Hippocampus · 2024Article
- Differential responses toward conditioned and unconditioned stimuli, but decreased hypothalamic-pituitary-adrenal axis responsiveness in neonatal hippocampal lesioned monkeys.Developmental cognitive neuroscience · 2022Article
- General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action.International journal of molecular sciences · 2022Review
- The Parahippocampal Cortex and its Functional Connection with the Hippocampus are Critical for Nonnavigational Spatial Memory in Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Hippocampal damage attenuates habituation to videos in monkeys.Hippocampus · 2019Article
- Nonnavigational spatial memory performance is unaffected by hippocampal damage in monkeys.Hippocampus · 2019Article
- Neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys.Behavioral neuroscience · 2018Article
- Article
- Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys.Brain structure & function · 2017Article
- An MRI study of the corpus callosum in monkeys: Developmental trajectories and effects of neonatal hippocampal and amygdala lesions.Developmental psychobiology · 2017Article
- Increased anxiety-like behaviors, but blunted cortisol stress response after neonatal hippocampal lesions in monkeys.Psychoneuroendocrinology · 2017Article
- Development of relational memory processes in monkeys.Developmental cognitive neuroscience · 2016Article
- Decreased functional connectivity in dorsolateral prefrontal cortical networks in adult macaques with neonatal hippocampal lesions: Relations to visual working memory deficits.Neurobiology of learning and memory · 2016Article
- Off to a Good Start: The Early Development of the Neural Substrates Underlying Visual Working Memory.Frontiers in systems neuroscience · 2016Review
- Hippocampal Volume Reduction in Humans Predicts Impaired Allocentric Spatial Memory in Virtual-Reality Navigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A wireless transmission neural interface system for unconstrained non-human primates.Journal of neural engineering · 2015Article
- Alterations of hippocampal projections in adult macaques with neonatal hippocampal lesions: a Diffusion Tensor Imaging study.NeuroImage · 2014Article
Corrections and comments
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3 authors.
Funding
Abstract
This study describes a novel spatial memory paradigm for monkeys and reports the effects of neonatal damage to the hippocampus on performance in adulthood. Monkeys were trained to forage in eight boxes hung on the walls of a large enclosure. Each box contained a different food item that varied in its intrinsic reward value, as determined from food preference testing. Monkeys were trained on a spatial and a cued version of the task. In the spatial task, the boxes looked identical and remained fixed in location whereas in the cued task, the boxes were individuated with colored plaques and changed location on each trial. Ten adult Rhesus macaques (5 neonatal sham-operated and 5 with neonatal neurotoxic hippocampal lesions) were allowed to forage once daily until they preferentially visited boxes containing preferred foods. The data suggest that all monkeys learned to discriminate preferred from nonpreferred food locations, but that monkeys with neonatal hippocampal damage committed significantly more working memory errors than controls in both tasks. Furthermore, following selective satiation, controls altered their foraging pattern to avoid the satiated food, whereas lesioned animals did not, suggesting that neonatal hippocampal lesions prohibit learning of specific food-place associations. We conclude that whereas an intact hippocampus is necessary to form specific item-in-place associations, in its absence, cortical areas may support more broad distinctions between food types that allow monkeys to discriminate places containing highly preferred foods.
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