Evidence map›Paper›PMID 23398025›Full record

ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2013

Minor histocompatibility antigens and the maternal immune response to the fetus during pregnancy.

Caitlin Linscheid, Margaret G Petroff

Abstract readReview
In one paragraph

Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  20. Clinical impact of H-Y alloimmunity.Immunologic research · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Caitlin LinscheidDepartment of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Margaret G Petroff

Funding

Research Design and Analysis Core (RDAC)P30HD002528 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI FOWLER, STEPHEN CLETIUS · 1985 to 2015
$22.1M
Maternal Tolerance to Fetal AlloantigensR01HD045611 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI PETROFF, MARGARET G · 2004 to 2014
$2.8M
NICHD NIH HHS P30 HD002528NICHD NIH HHS R01 HD045611
6 · The paper itself

Abstract

The tolerance of the semiallogeneic fetus by the maternal immune system is an important area of research for understanding how the maternal and fetal systems interact during pregnancy to ensure a successful outcome. Several lines of research reveal that the maternal immune system can recognize and respond to fetal minor histocompatibility antigens during pregnancy. Reactions to these antigens arise because of allelic differences between the mother and fetus and have been shown more broadly to play an important role in mediating transplantation outcomes. This review outlines the discovery of minor histocompatibility antigens and their importance in solid organ and hematopoietic stem cell transplantations, maternal T-cell responses to minor histocompatibility antigens during pregnancy, expression of minor histocompatibility antigens in the human placenta, and the potential involvement of minor histocompatibility antigens in the development and manifestation of pregnancy complications.

Indexed as

Immune ToleranceFemaleFetusHematopoietic Stem Cell TransplantationHistocompatibility, Maternal-FetalHLA AntigensHumansMinor Histocompatibility AntigensPlacentaPregnancyPregnancy ComplicationsT-LymphocytesHLA AntigensMinor Histocompatibility Antigens

Identifiers

PMID23398025
PMCPMC4048750

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.