SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
Null genotype of glutathione S-transferase T1 contributes to increased risk of gastric cancer in Asian population.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.
- N-acetyltransferase 2 status and gastric cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association between tumor necrosis factor β 252 A/G polymorphism and risk of gastric cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies were published to investigate the relationship between the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric cancer in Asians, but the conclusions from those studies were conflicting. To get a more precise estimation on the possible association, we performed a meta-analysis of published data. A comprehensive literature was conducted and 27 case-control studies with 14,905 individuals were finally included, involving a total of 6,270 cases and 8,635 controls. The strength of the association between GSTT1 polymorphism and gastric cancer risk was estimated by calculating the pooled odds ratio with its 95 % confidence interval (95 % CI). A meta-analysis of total 27 studies showed that GSTT1 null genotype was obviously associated with increased risk of gastric cancer in Asians (random effect odds ratio (OR) =1.29, 95 % CI 1.16-1.44, P OR<0.001). A subgroup analysis of 14 studies with large sample size also showed an obvious association between GSTT1 null genotype and increased risk of gastric cancer in Asians (fixed effect OR=1.14, 95 % CI 1.06-1.23, P OR=0.001). In conclusion, the meta-analysis suggests that null genotype of GSTT1 contributes to increased risk of gastric cancer in Asian population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.