ArticleSeminars in liver disease2012
Prevention and treatment of intestinal failure-associated liver disease in children.
Article in Seminars in liver disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Intestinal-Failure-Associated Liver Disease: Beyond Parenteral Nutrition.Biomolecules · 2025Review
- Pediatric Chronic Intestinal Failure: Something Moving?Nutrients · 2024Review
- Acquired Zinc Deficiency in Preterm Infant Post-Surgery for Necrotizing Enterocolitis (NEC) on Prolonged Total Parenteral Nutrition (TPN).Pediatric reports · 2024Article
- Histopathological liver steatosis linked with high parenteral glucose and amino acid supply in infants with short bowel syndrome.JPEN. Journal of parenteral and enteral nutrition · 2023Article
- Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications.Frontiers in pharmacology · 2020Review
- Evaluation of parenteral nutrition-associated liver disease in surgical infants for necrotizing enterocolitis.Medicine · 2020Observational
- Article
- Monitoring of long-term parenteral nutrition in children with intestinal failure.JGH open : an open access journal of gastroenterology and hepatology · 2019Review
- Intestinal failure: a review.F1000Research · 2018Review
- Preservation of biochemical liver function with low-dose soy-based lipids in children with intestinal failure-associated liver disease.Journal of pediatric gastroenterology and nutrition · 2015Article
- Clinical problem-solving: Short bowel syndrome in an infant.Paediatrics & child health · 2013Article
- New insights into intestinal failure-associated liver disease in adults: A comprehensive review of the literature.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intestinal failure-associated liver disease (IFALD), a serious complication occurring in infants, children, and adults exposed to long-term parenteral nutrition (PN), causes a wide-spectrum of disease, ranging from cholestasis and steatosis to fibrosis and eventually cirrhosis. Known host risk factors for IFALD include low birth weight, prematurity, short bowel syndrome, and recurrent sepsis. The literature suggests that components of PN may also play a part of the multifactorial pathophysiology. Because some intravenous lipid emulsions (ILEs) may contribute to inflammation and interfere with bile excretion, treatment with ILE minimization and/or ILEs composed primarily of omega-3 fatty acids can be helpful, but requires careful monitoring for growth failure and essential fatty acid deficiency (EFAD). Data from randomized controlled trials are awaited to support widespread use of these approaches. Other IFALD treatments include cycling PN, ursodeoxycholic acid, sepsis prevention, photoprotection, and polyvinylchloride-free tubing. Management and prevention of IFALD remains a clinical challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.