ReviewReviews in endocrine & metabolic disorders2013
The vascular endothelium in diabetes--a therapeutic target?
Review in Reviews in endocrine & metabolic disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Ischemic preconditioning as a modality to improve microvascular function and cardiometabolic risk in sedentary adults: a randomized controlled trial.European journal of applied physiology · 2026Trial
- Metabolic reprogramming and interventions in angiogenesis.Journal of advanced research · 2025Review
- Spotlight on iron and ferroptosis: research progress in diabetic retinopathy.Frontiers in endocrinology · 2023Review
- New insights into mechanisms of endothelial insulin resistance in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2022Review
- Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes.Oncotarget · 2017Article
- Cardiorespiratory Fitness and Cardiac Autonomic Function in Diabetes.Current diabetes reports · 2017Review
- Central Role of Metabolism in Endothelial Cell Function and Vascular Disease.Physiology (Bethesda, Md.) · 2017Review
- Article
- Acute effect of rosiglitazone on relaxation responses in hypercholesterolemic corpus cavernosum.International journal of impotence research · 2016Article
- Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- O-GlcNAcase overexpression reverses coronary endothelial cell dysfunction in type 1 diabetic mice.American journal of physiology. Cell physiology · 2015Article
- SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Role of habitual physical activity in modulating vascular actions of insulin.Experimental physiology · 2015Review
- Insulin action in muscle and adipose tissue in type 2 diabetes: The significance of blood flow.World journal of diabetes · 2015Review
- Effects of metformin on endothelial function in type 2 diabetes.Experimental and therapeutic medicine · 2014Article
- Treating Diabetes with Exercise - Focus on the Microvasculature.Journal of diabetes & metabolism · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Insulin resistance affects the vascular endothelium, and contributes to systemic insulin resistance by directly impairing the actions of insulin to redistribute blood flow as part of its normal actions driving muscle glucose uptake. Impaired vascular function is a component of the insulin resistance syndrome, and is a feature of type 2 diabetes. On this basis, the vascular endothelium has emerged as a therapeutic target where the intent is to improve systemic metabolic state by improving vascular function. We review the available literature presenting studies in humans, evaluating the effects of metabolically targeted and vascular targeted therapies on insulin action and systemic metabolism. Therapies that improve systemic insulin resistance exert strong concurrent effects to improve vascular function and vascular insulin action. RAS-acting agents and statins have widely recognized beneficial effects on vascular function but have not uniformly produced the hoped-for metabolic benefits. These observations support the notion that systemic metabolic benefits can arise from therapies targeted at the endothelium, but improving vascular insulin action does not result from all treatments that improve endothelium-dependent vasodilation. A better understanding of the mechanisms of insulin's actions in the vascular wall will advance our understanding of the specificity of these responses, and allow us to better target the vasculature for metabolic benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.