ArticleEvolutionary applications2013
An evolutionary explanation for the presence of cancer nonstem cells in neoplasms.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Natural products for intervertebral disc degeneration: mechanistic insights and therapeutic potentials.Frontiers in pharmacology · 2025Review
- Reuniting philosophy and science to advance cancer research.Biological reviews of the Cambridge Philosophical Society · 2023Article
- Reversible switching of leukemic cells to a drug-resistant, stem-like subset via IL-4-mediated cross-talk with mesenchymal stroma.Haematologica · 2022Article
- The effects of phenotypic plasticity on the fixation probability of mutant cancer stem cells.Journal of theoretical biology · 2020Article
- Inferring Tumor Proliferative Organization from Phylogenetic Tree Measures in a Computational Model.Systematic biology · 2020Article
- Metastasis and the evolution of dispersal.Proceedings. Biological sciences · 2019Article
- Big Bang Tumor Growth and Clonal Evolution.Cold Spring Harbor perspectives in medicine · 2018Review
- Optimizing homeostatic cell renewal in hierarchical tissues.PLoS computational biology · 2018Article
- Cooperation and cheating as innovation: insights from cellular societies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- A population genetics perspective on the determinants of intra-tumor heterogeneity.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Phenotypic heterogeneity in modeling cancer evolution.PloS one · 2017Article
- Principles of cooperation across systems: from human sharing to multicellularity and cancer.Evolutionary applications · 2016Article
- Cancer across the tree of life: cooperation and cheating in multicellularity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Evolution and phenotypic selection of cancer stem cells.PLoS computational biology · 2015Article
- Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?Disease models & mechanisms · 2014Review
- First principles of Hamiltonian medicine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- The development of a malignant tumor is due to a desperate asexual self-cloning process in which cancer stem cells develop the ability to mimic the genetic program of germline cells.Intrinsically disordered proteins · 2014Article
- Life history trade-offs in cancer evolution.Nature reviews. Cancer · 2013Review
- Evolutionary foundations for cancer biology.Evolutionary applications · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Contrary to conventional views that assume all cells in a neoplasm can propagate the tumor, the cancer stem cell hypothesis posits that only a fraction of the cells (the cancer stem cells) can act as tumor-propagating cells, while most of the tumor is composed of cells with limited replication potential. Here, we offer an evolutionary approach to this controversy. We used several evolutionary, computational models to investigate cancer cell dynamics and conditions consistent with the stem cell hypothesis. Our models predict that if selection acts at the cell level, neoplasms should be primarily comprised of cancer stem cells, in contrast to experimental data indicating that neoplasms contain large fractions of cancer nonstem cells. We explore several solutions explaining the paradoxical existence of cancer nonstem cells in neoplasms, including the possibility that selection acts at the level of multicellular proliferative units.
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Registered trials
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