Evidence map›Paper›PMID 23397293›Full record

ReviewArchives of pharmacal research2013

Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes.

Jongsoon Lee

Abstract readReview
In one paragraph

Review in Archives of pharmacal research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. The Role of TLRs in Obesity and Its Related Metabolic Disorders.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders.International journal of environmental research and public health · 2021
    Review
  18. Article
  19. GRP94 regulates M1 macrophage polarization and insulin resistance.American journal of physiology. Endocrinology and metabolism · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jongsoon LeeJoslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02115, USA. jongsoon.lee@joslin.harvard.edu

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
Determination of the role of adipocyte inflammation in obesity-induced insulin reR21DK080380 · NIDDK · JOSLIN DIABETES CENTER · PI LEE, JONGSOON · 2008 to 2009
$443k
FDA HHS RA 110BS97NIDDK NIH HHS DK046200NIDDK NIH HHS DK80380NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R21 DK080380
6 · The paper itself

Abstract

It has been increasingly accepted that chronic subacute inflammation plays an important role in the development of insulin resistance and type 2 diabetes in animals and humans. Particularly supporting this is that suppression of systemic inflammation in type 2 diabetes improves glycemic control; this also points to a new potential therapeutic target for the treatment of type 2 diabetes. Recent studies strongly suggest that obesity-induced inflammation is mainly mediated by tissue resident immune cells, with particular attention being focused on adipose tissue macrophages (ATMs). This review delineates the current progress made in understanding obesity-induced inflammation and the roles ATMs play in this process.

Indexed as

Adipose TissueAnimalsDiabetes Mellitus, Type 2HumansInflammationInsulin ResistanceMacrophagesObesity

Identifiers

PMID23397293
PMCPMC4086483

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.