ArticleIndian journal of pediatrics2013
B lymphocyte cytokine profile in a monozygotic twin pair discordant for nephrotic syndrome.
Article in Indian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors at 2 institutions in 1 country.
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Abstract
Nephrotic syndrome (NS) is the most common glomerular disorder of childhood and a leading cause of pediatric renal failure; however the etiology of NS remains largely unknown. Recent reports demonstrating that an anti-CD20 antibody can induce remission of NS strongly suggest a potentially novel role for B cells in NS pathogenesis. In this report, the authors investigated B cell cytokine profiles following in vitro stimulation in a monozygotic twin pair discordant for NS. The results revealed that clear differences in the cytokine profiles of B cells exist between the patient and the unaffected twin. This is the first report of altered B lymphocyte responses among a monozygotic twin pair that is discordant for NS. Future studies are needed to identify cytokine differences that track with NS relapse and/or NS response to therapy.
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