ArticleJournal of the American Society for Mass Spectrometry2013
Targeted multiplex imaging mass spectrometry in transmission geometry for subcellular spatial resolution.
Article in Journal of the American Society for Mass Spectrometry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Mass spectrometry imaging tutorial: From cancer biomarker discovery to clinical applications.Analytica chimica acta · 2026Review
- Instrumentation development, improvement, simplification, and miniaturization: The multifunctional plate source for use in mass spectrometry.European journal of mass spectrometry (Chichester, England) · 2023Article
- Review
- Simultaneous Multiplexed Imaging of Biomolecules in Transgenic Mouse Brain Tissues Using Mass Spectrometry Imaging: A Multi-omic Approach.Analytical chemistry · 2022Article
- Single-Cell Metabolomics by Mass Spectrometry Imaging.Advances in experimental medicine and biology · 2021Article
- Effect of MALDI matrices on lipid analyses of biological tissues using MALDI-2 postionization mass spectrometry.Journal of mass spectrometry : JMS · 2020Article
- Conjugating immunoassays to mass spectrometry: Solutions to contemporary challenges in clinical diagnostics.Trends in analytical chemistry : TRAC · 2020Review
- Mass spectrometry imaging to detect lipid biomarkers and disease signatures in cancer.Cancer reports (Hoboken, N.J.) · 2019Review
- Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue.Diabetologia · 2019Article
- Computer aided analysis of disease linked protein networks.Bioinformation · 2019Article
- Toward Mass Spectrometry Imaging in the Metabolomics Scale: Increasing Metabolic Coverage Through Multiple On-Tissue Chemical Modifications.Frontiers in plant science · 2019Article
- Five Micron High Resolution MALDI Mass Spectrometry Imaging with Simple, Interchangeable, Multi-Resolution Optical System.Journal of the American Society for Mass Spectrometry · 2017Article
- High resolution laser mass spectrometry bioimaging.Methods (San Diego, Calif.) · 2016Review
- High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling.Journal of mass spectrometry : JMS · 2015Article
- Tissue protein imaging at 1 μm laser spot diameter for high spatial resolution and high imaging speed using transmission geometry MALDI TOF MS.Analytical and bioanalytical chemistry · 2015Article
- MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery.Journal of proteomics · 2014Review
- Advanced mass spectrometry technologies for the study of microbial pathogenesis.Current opinion in microbiology · 2014Article
- Analysis of biomolecules by atmospheric pressure visible-wavelength MALDI-ion trap-MS in transmission geometry.Journal of the American Society for Mass Spectrometry · 2013Article
- Mass spectrometry imaging for plant biology: a review.Phytochemistry reviews : proceedings of the Phytochemical Society of EuropeReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Targeted multiplex imaging mass spectrometry utilizes several different antigen-specific primary antibodies, each directly labeled with a unique photocleavable mass tag, to detect multiple antigens in a single tissue section. Each photocleavable mass tag bound to an antibody has a unique molecular weight and can be readily ionized by laser desorption ionization mass spectrometry. This article describes a mass spectrometry method that allows imaging of targeted single cells within tissue using transmission geometry laser desorption ionization mass spectrometry. Transmission geometry focuses the laser beam on the back side of the tissue placed on a glass slide, providing a 2 μm diameter laser spot irradiating the biological specimen. This matrix-free method enables simultaneous localization at the sub-cellular level of multiple antigens using specific tagged antibodies. We have used this technology to visualize the co-expression of synaptophysin and two major hormones peptides, insulin and somatostatin, in duplex assays in beta and delta cells contained in a human pancreatic islet.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.