ArticleEvolutionary applications2013
Applying ecological and evolutionary theory to cancer: a long and winding road.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 81 citations in OpenAlex.
- Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer.Nature communications · 2017Trial
- Explanations for failures in designed and evolved systems.PNAS nexus · 2025Article
- An evolutionary differential game for regulating the role of monoclonal antibodies in treating signalling pathways in oesophageal cancer.Royal Society open science · 2024Article
- Marine transmissible cancer navigates urbanized waters, threatening spillover.Proceedings. Biological sciences · 2024Article
- Onco-Breastomics: An Eco-Evo-Devo Holistic Approach.International journal of molecular sciences · 2024Review
- Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production.Science advances · 2023Article
- Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes.Molecular biology and evolution · 2022Article
- Review
- The influence of evolutionary history on human health and disease.Nature reviews. Genetics · 2021Review
- CancerFrontiers in immunology · 2021Article
- Eco-oncology: Applying ecological principles to understand and manage cancer.Ecology and evolution · 2020Review
- Cancer Ecology and Evolution: Positive interactions and system vulnerability.Current opinion in systems biology · 2019Article
- Tracing the rise of malignant cell lines: Distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils.Evolutionary applications · 2019Article
- Folate Repletion after Deficiency Induces Irreversible Genomic and Transcriptional Changes in Human Papillomavirus Type 16 (HPV16)-Immortalized Human Keratinocytes.International journal of molecular sciences · 2019Article
- Short- and long-term evolution in our arms race with cancer: Why the war on cancer is winnable.Evolutionary applications · 2018Article
- Turning natural adaptations to oncogenic factors into an ally in the war against cancer.Evolutionary applications · 2018Article
- Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer.Cold Spring Harbor perspectives in medicine · 2017Review
- PhyloOncology: Understanding cancer through phylogenetic analysis.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Cancer: A disease at the crossroads of trade-offs.Evolutionary applications · 2017Article
- Molecular and cellular bases of adaptation to a changing environment in microorganisms.Proceedings. Biological sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 13 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.