ArticleEvolutionary applications2013
Modelling the evolution of genetic instability during tumour progression.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Stochastic Evolutionary Control in Heterogeneous Populations.bioRxiv : the preprint server for biology · 2026Article
- Towards evolutionary guided precision medicine of acute myeloid leukemia and Fanconi anemia associated bone marrow failure.Stem cells translational medicine · 2026Article
- Extinction scenarios in evolutionary processes: a multinomial Wright-Fisher approach.Journal of mathematical biology · 2023Article
- Single-cell phylogenies reveal changes in the evolutionary rate within cancer and healthy tissues.Cell genomics · 2023Article
- Clonal evolution driven by superdriver mutations.BMC evolutionary biology · 2020Article
- Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis.Nature communications · 2020Article
- Resolving genetic heterogeneity in cancer.Nature reviews. Genetics · 2019Review
- Genomic clustering of fitness-affecting mutations favors the evolution of chromosomal instability.Evolutionary applications · 2019Article
- Adaptive dynamics of unstable cancer populations: The canonical equation.Evolutionary applications · 2018Article
- Review
- Blood vessel tortuosity selects against evolution of aggressive tumor cells in confined tissue environments: A modeling approach.PLoS computational biology · 2017Article
- Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations.Scientific reports · 2016Article
- Long range personalized cancer treatment strategies incorporating evolutionary dynamics.Biology direct · 2016Article
- The rich phase structure of a mutator model.Scientific reports · 2016Article
- Dynamic changes of driver genes' mutations across clinical stages in nine cancer types.Cancer medicine · 2016Article
- Evolution of genetic instability in heterogeneous tumors.Journal of theoretical biology · 2016Article
- The implications of small stem cell niche sizes and the distribution of fitness effects of new mutations in aging and tumorigenesis.Evolutionary applications · 2016Article
- Modeling Tumor Clonal Evolution for Drug Combinations Design.Trends in cancer · 2016Review
- A Big Bang model of human colorectal tumor growth.Nature genetics · 2015Article
- Identifying restrictions in the order of accumulation of mutations during tumor progression: effects of passengers, evolutionary models, and sampling.BMC bioinformatics · 2015Article
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5 authors.
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Abstract
The role of genetic instability in driving carcinogenesis remains controversial. Genetic instability should accelerate carcinogenesis by increasing the rate of advantageous driver mutations; however, genetic instability can also potentially retard tumour growth by increasing the rate of deleterious mutation. As such, it is unclear whether genetically unstable clones would tend to be more selectively advantageous than their genetically stable counterparts within a growing tumour. Here, we show the circumstances where genetic instability evolves during tumour progression towards cancer. We employ a Wright-Fisher type model that describes the evolution of tumour subclones. Clones can acquire both advantageous and deleterious mutations, and mutator mutations that increase a cell's intrinsic mutation rate. Within the model, cancers evolve with a mutator phenotype when driver mutations bestow only moderate increases in fitness: very strong or weak selection for driver mutations suppresses the evolution of a mutator phenotype. Genetic instability occurs secondarily to selectively advantageous driver mutations. Deleterious mutations have relatively little effect on the evolution of genetic instability unless selection for additional driver mutations is very weak or if deleterious mutations are very common. Our model provides a framework for studying the evolution of genetic instability in tumour progression. Our analysis highlights the central role of selection in shaping patterns of mutation in carcinogenesis.
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