ArticleNucleic acids research2013
A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- MiR-326: Role and significance in brain cancers.Non-coding RNA research · 2025Review
- Exosomes Derived from E2F1International journal of nanomedicine · 2023Article
- Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair.Frontiers in bioengineering and biotechnology · 2023Review
- MicroRNA governs bistable cell differentiation and lineage segregation via a noncanonical feedback.Molecular systems biology · 2021Article
- Downregulation of miR-326 and its host gene β-arrestin1 induces pro-survival activity of E2F1 and promotes medulloblastoma growth.Molecular oncology · 2021Article
- Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow.Frontiers in genetics · 2021Article
- miR‑329‑3p regulates neural stem cell proliferation by targeting E2F1.Molecular medicine reports · 2019Article
- The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster.Frontiers in genetics · 2019Article
- miR-1297 regulates neural stem cell differentiation and viability through controlling Hes1 expression.Cell proliferation · 2017Article
- An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells.Scientific reports · 2017Article
- Long nonding RNA UCA1 regulates neural stem cell differentiation by controlling miR-1/Hes1 expression.American journal of translational research · 2017Article
- Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke.Stem cells international · 2017Review
- Profiling analysis of circulating microRNA in peripheral blood of patients with class IV lupus nephritis.PloS one · 2017Article
- The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs.Nucleic acids research · 2015Article
- Nervous decision-making: to divide or differentiate.Trends in genetics : TIG · 2014Review
- Stem cell characteristics in glioblastoma are maintained by the ecto-nucleotidase E-NPP1.Cell death and differentiation · 2014Article
- The miR-7 identified from collagen biomaterial-based three-dimensional cultured cells regulates neural stem cell differentiation.Stem cells and development · 2014Article
- Role of miRNAs and epigenetics in neural stem cell fate determination.Epigenetics · 2014Review
- Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules.PLoS genetics · 2014Article
- Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq.Genome biology · 2014Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell fate decisions are controlled by a molecular network in which transcription factors and miRNAs are of key importance. To systemically investigate their impact on neural stem cell (NSC) maintenance and neuronal commitment, we performed a high-throughput mRNA and miRNA profiling and isolated functional interaction networks of involved mechanisms. Thereby, we identified an E2F1-miRNA feedback loop as important regulator of NSC fate decisions. Although E2F1 supports NSC proliferation and represses transcription of miRNAs from the miR-17∼92 and miR-106a∼363 clusters, these miRNAs are transiently up-regulated at early stages of neuronal differentiation. In these early committed cells, increased miRNAs expression levels directly repress E2F1 mRNA levels and inhibit cellular proliferation. In mice, we demonstrated that these miRNAs are expressed in the neurogenic areas and that E2F1 inhibition represses NSC proliferation. The here presented data suggest a novel interaction mechanism between E2F1 and miR-17∼92 / miR-106a∼363 miRNAs in controlling NSC proliferation and neuronal differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.