ArticleNature neuroscience2013
Cellular mechanisms of spatial navigation in the medial entorhinal cortex.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers.
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Who cites it
153 citing papers in PubMed, 287 citations in OpenAlex.
- Beyond traditional assessments of cognitive status: Exploring the potential of spatial navigation tasks.Behavior research methods · 2026Article
- Human hippocampal theta-gamma coupling coordinates sequential planning during navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology.Molecular psychiatry · 2026Article
- Bifurcation of spiking oscillations from a center in resonate-and-fire neurons.Biological cybernetics · 2026Article
- Distinctive roles of left and right entorhinal cortex in path integration via a non-invasive stimulation study.Nature communications · 2025Article
- Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space.bioRxiv : the preprint server for biology · 2025Article
- DomeVR: Immersive virtual reality for primates and rodents.PloS one · 2025Article
- Learning-dependent gating of hippocampal inputs by frontal interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Adult zebrafish can learn Morris water maze-like tasks in a two-dimensional virtual reality system.Cell reports methods · 2024Article
- Ketamine evoked disruption of entorhinal and hippocampal spatial maps.Nature communications · 2023Article
- Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex.bioRxiv : the preprint server for biology · 2023Article
- Phase information is conserved in sparse, synchronous population-rate-codes via phase-to-rate recoding.Nature communications · 2023Article
- Simulation of oscillatory dynamics induced by an approximation of grid cell output.Reviews in the neurosciences · 2023Review
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- Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus.Hippocampus · 2023Review
- Article
- Heterogeneous stochastic bifurcations explain intrinsic oscillatory patterns in entorhinal cortical stellate cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cell-Type Specific Inhibition Controls the High-Frequency Oscillations in the Medial Entorhinal Cortex.International journal of molecular sciences · 2022Article
- Article
93 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neurons in the medial entorhinal cortex exhibit a grid-like spatial pattern of spike rates that has been proposed to represent a neural code for path integration. To understand how grid cell firing arises from the combination of intrinsic conductances and synaptic input in medial entorhinal stellate cells, we performed patch-clamp recordings in mice navigating in a virtual-reality environment. We found that the membrane potential signature of stellate cells during firing field crossings consisted of a slow depolarization driving spike output. This was best predicted by network models in which neurons receive sustained depolarizing synaptic input during a field crossing, such as continuous attractor network models of grid cell firing. Another key feature of the data, phase precession of intracellular theta oscillations and spiking with respect to extracellular theta oscillations, was best captured by an oscillatory interference model. Thus, these findings provide crucial new information for a quantitative understanding of the cellular basis of spatial navigation in the entorhinal cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.