Evidence map›Paper›PMID 23395943›Full record

ReviewJournal of health care for the poor and underserved2013

Phytoalexins, miRNAs and breast cancer: a review of phytochemical-mediated miRNA regulation in breast cancer.

Syreeta L Tilghman, Lyndsay V Rhodes, Melyssa R Bratton, Patrick Carriere, Lynez C Preyan, Stephen M Boue, Tadas Sean Vasaitis, John A McLachlan, Matthew E Burow

Abstract readReview
In one paragraph

Review in Journal of health care for the poor and underserved, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Molecular Targets of Natural Compounds with Anti-Cancer Properties.International journal of molecular sciences · 2021
    Review
  2. Article
  3. Article
  4. Review
  5. Bioscience reports · 2018
    Article
  6. Review
  7. Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1.International journal of environmental research and public health · 2015
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Syreeta L TilghmanDivision of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA.
Lyndsay V Rhodes
Melyssa R Bratton
Patrick Carriere
Lynez C Preyan
Stephen M Boue
Tadas Sean Vasaitis
John A McLachlan
Matthew E Burow
Xavier University of Louisiana · US

Funding

Xavier's RCMI Cancer Research ProgramG12MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE, WANG, GUANGDI · 2012 to 2018
$15.7M
XAVIER'S RCMI CANCER RESEARCH PROGRAMG12RR026260 · NCRR · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE · 2009 to 2011
$7.0M
NCRR NIH HHS 5G12RR026260NCRR NIH HHS G12 RR026260NIMHD NIH HHS G12 MD007595
6 · The paper itself

Abstract

There is growing interest in the diverse signaling pathways that regulate and affect breast tumorigenesis, including the role of phytochemicals and the emerging role of microRNAs (miRNAs). Recent studies demonstrate that miRNAs regulate fundamental cellular and developmental processes at the transcriptional and translational level under normal and disease conditions. While there is growing evidence to support the role of phytoalexin-mediated miRNA regulation of cancer, few reports address this role in breast cancer. Recent reports by our group and others demonstrate that natural products, including stilbenes, curcumin, and glyceollins, could alter the expression of specific miRNAs, which may lead to increased sensitivity of cancer cells to conventional anti-cancer agents and, therefore, hormone-dependent and hormone-independent tumor growth inhibition. This review will discuss how dietary intake of natural products, by regulating specific miRNAs, contribute to the prevention and treatment of breast cancer.

Indexed as

Gene Expression Regulation, NeoplasticBreast NeoplasmsFemaleHumansMicroRNAsPhytoalexinsSesquiterpenesMicroRNAsPhytoalexinsSesquiterpenes

Identifiers

PMID23395943
PMCPMC3628743
OpenAlexW2008051089

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.